Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

BMC Medical Genetics

Table 4 Polymorphisms in modifier genes associated with numerical variables of cystic fibrosis severity

*CFTR*group	Variable	Polymorphism	Genotype	N	Mean	SD	SEM	p- value corrected
Without taking CFTR mutation into account	Bhalla score^a	GCLC-3506A > G	AA	94	19.70	6.007	0.620	0.044
Without taking CFTR mutation into account	Bhalla score^a	GCLC-3506A > G	AG + GG	43	17.00	5.033	0.768	0.044
No mutation identified	SpO2^a	GSTT1 deletion	Not expressed	15	96.13	2.232	0.576	0.048
	SpO2^a	GSTT1 deletion	Expressed	29	93.17	5.245	0.974	0.048
	Bhalla score^b	GSTM1/GSTT1 deletions	−/−	4	14.75	1.258	0.629	0.02
			+/− and −/+	21	6.900	6.610	1.442
			+/+	9	15.33	7.533	2.511

^aUsing Student’s t-test; ^bUsing analysis of variance.
CFTR, Cystic fibrosis transmembrane regulator; SpO2, Hemoglobin oxygen saturation in the blood; −, Null allele; +, Expressed allele; N, Number of patients.

ISSN: 1471-2350