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Table 2 Selected SNPs (based on location within gene encoding protein of known function or disease association) showing suggestive association with TdT analysis (p < 0.0001) to BD in our validation dataset (small family cohort)

From: Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

Chr SNP bp A1/A2 T/UT TDT OR P value Chisq Gene Comments/MIM #
1 rs575056 66522367 C/T 49/96 0.5104 9.5E-05 15.23 PDE4B Protein interacts with DISC1, and is considered a candidate gene for BD and SCZ; MIM 600127
1 rs538336 66545251 G/A 63/116 0.5431 7.45E-05 15.69 PDE4B MIM 600127
6 rs2852571 102108785 T/G 96/47 2.043 4.18E-05 16.79 GRIK2 Kainate glutamate receptor; homozygous mutations are associated with intellectual disability; MIM 138244
10 rs7074934 26571676 G/A 4/28 0.1429 2.21E-05 18 GAD2 Glutamate decarboxylase, responsible for converting L-glutamic acid to GABA; MIM 138275
10 rs17647803 83730201 G/A 11/45 0.2444 5.53E-06 20.64 NRG3 Member of neuregulin gene family, associated with BD and SCZ; MIM 605533
11 rs1893050 84305742 C/T 3/24 0.125 5.31E-05 16.33 DLG2 Post-synaptic density protein; MIM 603583
12 rs11065615 109214996 T/C 2/23 0.08696 2.67E-05 17.64 ATP2A2 MIM 107840; Mutations in this gene cause Darier disease (MIM 124200)
15 rs140673 25155075 C/A 8/35 0.2286 3.83E-05 16.95 GABRG3 GABA-A receptor; MIM 600233
16 rs7186123 81379253 G/T 20/54 0.3704 7.74E-05 15.62 CDH13 Cadherin gene associated with autism, also alcohol dependency; MIM 601364
  1. The full list of 132 SNPs showing suggestive association (p < 0.0001) is given in Additional file 1: Table S3. Mendelian Inheritance in Man (MIM) number is included in comments, as a source of reference. Chr = chromosome; SNP = single nucleotide polymorphism; bp (base pair) indicates coordinates according to build hg18/NCBI36. Alleles are indicated in A1/A2. Transmitted (T) and untransmitted (UT) allele counts are given (T/UT), also odds ratio (OR) for the transmission disequilibrium test) TDT, and chisquare (Chisq) value.
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