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Table 2 Associations of common variants with type 2 diabetes in urban Ghana

From: The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based case–control study

Gene SNP Genotype N Controls Type 2 diabetes OR (9% CI) P aOR (95% CI)a P
TCF7L2 rs7903146 n 1049 375 674     
  C/C 455 182 (48.5) 273 (40.5) Reference    
  C/T 488 165 (44.0) 323 (47.9)     
  T/T 106 28 (7.5) 78 (11.6) 1.34 (1.10–1.63) 0.004 1.39 (1.07–1.81) 0.014
  MAF (T)   0.30 0.36     
KCNJ11 rs5219 n 1052 377 675     
  A/A 1051 377 (100) 674 (99.9) Reference    
  A/G 1 0 (0) 1 (0.1)     
  G/G 0 0 (0) 0 (0) -   -  
  MAF (G)   0.0 0.0007     
PPARγ rs1801282 n 1021 365 656     
  C/C 1020 365 (100) 655 (99.8) Reference    
  C/G 1 0 (0) 1 (0.2)     
  G/G 0 0 (0) 0 (0) -   -  
  MAF (G)   0.0 0.0008     
CAPN10 rs3792267 n 1048 375 673     
  G/G 826 289 (77.1) 537 (79.8) Reference    
  G/A 209 80 (21.3) 129 (19.2)     
  A/A 13 6 (1.6) 7 (1.0) 0.85 (0.64–1.12) 0.25 0.70 (0.47–1.03) 0.07
  MAF (A)   0.13 0.11     
CAPN10 rs3842570 n 1048 374 674     
  2 repeats/2 repeats 622 225 (60.2) 397 (58.9) Reference    
  2 repeats/3 repeats 376 128 (34.2) 248 (36.8)     
  3 repeats/3 repeats 50 21 (5.6) 29 (4.3) 1.00 (0.80–1.24) 0.99 1.12 (0.84–1.49) 0.45
  MAF (3 repeats)   0.23 0.23     
CAPN10 rs5030952 n 1048 374 674     
  C/C 219 79 (21.1) 140 (20.8) Reference    
  C/T 523 182 (48.7) 341 (50.6)     
  T/T 306 113 (30.2) 193 (28.6) 0.98 (0.81–1.17) 0.79 0.98 (0.76–1.25) 0.84
  MAF (T)   0.55 0.54     
  1. MAF, minor allele frequency. a, The multivariate odds ratio is adjusted for age, gender, BMI ≥25.0 kg/m2 and hypertension status.