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Table 4 Correlations between polymorphisms in DNA repair genes, comet assay and BMCyt assay in COPD patients

From: Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes

Parameters XRCC1 OGG1 XRCC3
  Risk allele Risk allele Risk allele
  (ArgGln+GlnGln) (SerCys+CysCys) (ThrMet+MetMet)
  Spearman’s rho p value Spearman’s rho p value Spearman’s rho p value
% Residual damage- basal DI in alkaline comet assay −0.497 0.007 NS NS NS NS
% Residual damage- basal DI in neutral comet assay −0.495 0.007 NS NS NS NS
% Residual damage- BI NS NS NS NS 0.350 0.036
% Residual damage- KR NS NS NS NS 0.444 0.007
FEV1- basal DI in alkaline comet assay NS NS NS NS 0.336 0.045
FEV1− CC −0.404 0.029 NS NS NS NS
FEV1− KR −0.398 0.044 NS NS NS NS
FEV1/ FVC- KR −0.441 0.024 NS NS −0.408 0.013
FEV1/ FVC- BUD NS NS NS NS −0.357 0.032
FEV1/ FVC- BI NS NS NS NS −0.328 0.051
FVC- CC −0.428 0.029 −0.645 0.024 −0.343 0.041
FVC- basal DI in alkaline comet assay NS NS NS NS 0.423 0.010
PY- basal DI in neutral comet assay NS NS −0.643 0.024 NS NS
PY- basal DI in alkaline comet assay NS NS −0.616 0.033 NS NS
Basal cell- CC 0.442 0.032 NS NS NS NS
Basal cell- MN NS NS NS NS 0.381 0.022
Basal cell- BUD NS NS NS NS 0.467 0.004
Basal cell- KL NS NS −0.666 0.018 −0.359 0.032
  1. FEV 1 , forced expiratory volume in one second; FVC, forced vital capacity; DI, damage index; % Residual damage - calculated for DI after 3 h MMS treatment for each subject taking the value of DI after 1 h MMS treatment as 100%; BI, Binucleated cells; KR, Karyorrhectic cells; CC, Condensed chromatin cells; BUD, Nuclear Buds cells; PY, Pyknotic cells; MN, Micronuclei; KL, Karyolytic cells. Statistical analysis was performed by Spearman Correlation test.