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Table 3 Comet assay effects in COPD and controls stratified by genetic polymorphisms in base excision repair (BER), homologous recombination (HR) and nonhomologous DNA end joining (NHEJ) repair genes

From: Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes

  COPD CONTROL p*
BER    
Subjects n= 28 n=26  
XRCC1- Arg399Gln (ArgGln+GlnGln) (ArgGln+GlnGln)  
COMET ASSAY    
 DI Alkaline 37.29±27.84 21.04±24.45 0.005
 DI Neutral 46.50±41.42 29.00±34.46 0.049
 DI Residual 150.89±87.99 51.88±44.20 0.000
Subjects n= 13 n=15  
OGG1- Ser326Cys (SerCys+CysCys) (SerCys+CysCys)  
COMET ASSAY    
 DI Alkaline 45.54±30.36 41.60±35.05 NS
 DI Neutral 60.54±31.63 55.27±47.68 NS
 DI Residual 142.38±92.56 56.00±34.98 0.001
HR and NHEJ    
Subjects n= 36 n=36  
XRCC 3- Thr241Met (ThrMet+MetMet) (ThrMet+MetMet)  
COMET ASSAY    
 DI Alkaline 36.56±24.67 22.50±23.49 0.009
 DI Neutral 48.50±30.55 34.53±37.79 0.039
 DI Residual 134.75±77.16 54.06±42.88 0.000
Subjects n= 11 n=07  
XRCC 4- Ile401Thr (IIeThr+ThrThr) (IIeThr+ThrThr)  
COMET ASSAY    
 DI Alkaline 36.64±23.80 22.36±24.10 NS
 DI Neutral 47.36±28.15 36.43±37.30 NS
 DI Residual 134.50±80.74 49.02±36.07 0.013
  1. Data are presented as mean ± SD; DI, damage index; NS, nonsignificant;* Kruskal- Wallis Test.