Table 3 Comet assay effects in COPD and controls stratified by genetic polymorphisms in base excision repair (BER), homologous recombination (HR) and nonhomologous DNA end joining (NHEJ) repair genes
From: Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes
COPD | CONTROL | p* | |
|---|---|---|---|
BER | |||
Subjects | n= 28 | n=26 | |
XRCC1- Arg399Gln | (ArgGln+GlnGln) | (ArgGln+GlnGln) | |
COMET ASSAY | |||
DI Alkaline | 37.29±27.84 | 21.04±24.45 | 0.005 |
DI Neutral | 46.50±41.42 | 29.00±34.46 | 0.049 |
DI Residual | 150.89±87.99 | 51.88±44.20 | 0.000 |
Subjects | n= 13 | n=15 | |
OGG1- Ser326Cys | (SerCys+CysCys) | (SerCys+CysCys) | |
COMET ASSAY | |||
DI Alkaline | 45.54±30.36 | 41.60±35.05 | NS |
DI Neutral | 60.54±31.63 | 55.27±47.68 | NS |
DI Residual | 142.38±92.56 | 56.00±34.98 | 0.001 |
HR and NHEJ | |||
Subjects | n= 36 | n=36 | |
XRCC 3- Thr241Met | (ThrMet+MetMet) | (ThrMet+MetMet) | |
COMET ASSAY | |||
DI Alkaline | 36.56±24.67 | 22.50±23.49 | 0.009 |
DI Neutral | 48.50±30.55 | 34.53±37.79 | 0.039 |
DI Residual | 134.75±77.16 | 54.06±42.88 | 0.000 |
Subjects | n= 11 | n=07 | |
XRCC 4- Ile401Thr | (IIeThr+ThrThr) | (IIeThr+ThrThr) | |
COMET ASSAY | |||
DI Alkaline | 36.64±23.80 | 22.36±24.10 | NS |
DI Neutral | 47.36±28.15 | 36.43±37.30 | NS |
DI Residual | 134.50±80.74 | 49.02±36.07 | 0.013 |