Figure 4

Muscle biopsy. (A) H&E staining of a muscle biopsy of the left anterior tibial muscle with mild myopathic changes indicated by muscle fiber splitting and increase in endomysial connective tissue. Additionally, in the ATPase pH 4.1 staining (B), a type I fiber predominance without evidence of fiber type grouping and numerous hypertrophic type I fibers are notable. Bars in A and B adjusted to 50 μm.