Genetics of coronary artery calcification among African Americans, a meta-analysis

BMC Medical Genetics

Table 1 Participant characteristics of eight participating African-American cohorts

*CARDIA: Year 20 data; hypertension by self-report.
† JHS CAC data comprised of the JHS de novo recruited sample “JHS” (n = 1066) and the JHS sample previously enrolled in the ARIC study, denoted “JHS-ARIC” (n = 322). CAC data were collected in all JHS participants (JHS and JHS-ARIC) through JHS NHLBI funding. The JHS-de novo recruited sample was genotyped as a batch via the CARe study at the Broad Institute. Genotyping of all AA ARIC participants also was performed as a separate batch via the CARe study at the Broad Institute. The recommendation from the CARe study analysis committee was to analyze the” JHS” and “JHS-ARIC” individuals separately because QC of JHS and ARIC genotype data was not 100% identical.
‡MESA Family/Air: heritability based on n = 882 in families from participants of MESA Family.
§GeneSTAR: hypertension = average of 3 measures ≥ 140/90 mmHg and/or current use of antihypertensive medication; GENOA: Self-reported hypertension. Statin use data was not available; MESA Family/Air: hypertension if diastolic > =90 or systolic > =140; or self-reported high blood pressure and on meds for hypertension; FamHS, CARDIA, MESA, JHS: hypertension = measure ≥140/90 mm Hg and/or current use of antihypertensive medication.

ISSN: 1471-2350