Identification of novel mutation in cathepsin C gene causing Papillon-Lefèvre Syndrome in Mexican patients

BMC Medical Genetics

Table 3 Allele frequencies (af) of the more common HLA class I and II molecules found in patients with Papillon-Lefèvre Syndrome, their relatives and controls

Alleles	Patients		Relatives		Controls
	(N = 18)		(N = 30)		(N = 82)
HLA-A		af		af		af
A*24	6	0.3333	8	0.2667	12	0.1463
A*02	3	0.1667	4	0.1333	24	0.2927
A*33	3	0.1667	2	0.0667	1	0.0122
A*31	2	0.1111	5	0.1667	8	0.0976
A*03	2	0.1111	2	0.0667	2	0.0244
HLA-B
B*35	6	0.3333	9	0.3000	17	0.2073
B*65	3	0.1667	2	0.0667	2	0.0244
B*44	2	0.1111	2	0.0667	9	0.1098
B*51	1	0.0556	2	0.0667	4	0.0488
B*60	1	0.0556	2	0.0667	3	0.0366
HLA-DRB1
DRB1*11	6	0.3333	6	0.2000	6	0.0732
DRB1*04	4	0.2222	9	0.3000	20	0.2439
DRB1*01	3	0.1667	6	0.2000	13	0.1585
DRB1*15	3	0.1667	4	0.1333	3	0.0366
DRB1*07	1	0.0556	2	0.0667	8	0.0976
HLA-DQB1
DQB1*0301	7	0.3889	9	0.3000	20	0.2439
DQB1*0302	4	0.2222	9	0.3000	14	0.1707
DQB1*0501	4	0.2222	4	0.1333	9	0.1098
DQB1*0601	2	0.1111	2	0.0667	8	0.0976
DQB1*0201	1	0.0556	5	0.1667	14	0.1707

ISSN: 1471-2350