Family pedigrees of the patients with an identified BRCA2 c.658delGT (A-E) and c.646delG (F-H) mutation. A family pedigree of patient from HBOC group, A – H – patients from consecutive patients group. Breast cancer patients are marked in black. Patients with other cancer localization are marked in gray (Pro, prostate; Ut, uterus; Bl, bladder; HN, head and neck; St, stomach). The patients in whom BRCA2 mutations were found by molecular screening are indicated by arrows and information about mutation added to proband.