Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study

Table 3 Complete meta-analysis results for African-Americans, effect size expressed in terms of % difference in mean BMI

					Current smokers			Former/never smokers			Combined sex and smoking status*
Gene	SNP	CA	sex	p-value for interaction	% difference in mean BMI (95% CI)	p-value	N	% difference in mean BMI (95% CI)	p-value	N	% difference in mean BMI (95% CI)	p-value	N	AF
GNPDA2	rs10938397	G	F	0.60	0.5 (-0.9 - 1.92)	0.50	1848	1.51 (0.6 - 2.43)	9.2E-04	7664	0.91 (0.3 - 1.41)	1.5E-03	14383	0.24
GNPDA2	rs10938397	G	M	0.78	1.31 (-0.1 - 2.63)	0.06	1455	1.51 (0.4 - 2.53)	6.9E-03	2831	0.91 (0.3 - 1.41)	1.5E-03	14383	0.24
MC4R	rs17782313	C	F	0.53	−0.8 (-2.08 - 0.6)	0.27	1758	0.6 (-0.2 - 1.51)	0.15	7365	0.6 (0.03 - 1.11)	4.0E-02	13698	0.29
MC4R	rs17782313	C	M	0.31	−0.1 (-1.29 - 1.21)	0.93	1339	1.21 (0.2 - 2.22)	0.02	2682	0.6 (0.03 - 1.11)	4.0E-02	13698	0.29
FTO	rs3751812	T	F	0.34	−0.1 (-2.76 - 2.63)	0.94	774	0.4 (-1.09 - 1.92)	0.61	4505	0.4 (-1.11 - 2.01)	0.60	4549	0.12
FTO	rs3751812	T	M	0.61	2.53 (0.2 - 4.92)	3.0E-02	329	1.51 (-0.3 - 3.25)	0.11	565	0.4 (-1.11 - 2.01)	0.60	4549	0.12
TMEM18	rs6548238	C	F	0.10	0.1 (-1.78 - 2.02)	0.95	1876	1.82 (0.7 - 2.94)	0.002	7707	1.31 (0.6 - 2.01)	2.4E-04	14492	0.88
			M	0.64	2.43 (0.7 - 4.08)	0.01	1463	0.9 (-0.4 - 2.22)	0.18	2855

CA Coded allele, M male, F female, CI confidence interval, AF coded allele frequency.

ISSN: 1471-2350