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Table 1 Comparison of the metabolic abnormalities between glucose tolerance and fatty liver

From: Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver

Groups/variables

Normal Glucose Tolerance (NGT)

Glucose Intolerance (GI)

Pfor effect of FL vs AFL

Pfor effect of GI vs NGT

Pfor interaction of FL and GI

AFL (n = 323)

FL (n = 406)

AFL (n = 98)

FL (n = 201)

Age (yrs)

45.63 ± 8.10

44.60 ± 8.65

48.68 ± 6.89

49.21 ± 8.69

0.675

< 0.0001

0.195

BMI (kg/m2)

23.16 ± 2.51

25.64 ± 3.06*

22.79 ± 3.31

26.16 ± 3.03*

< 0.0001

0.716

0.035

Serum insulin (μIU/ml)

2.22 ± 2.47

4.28 ± 4.48*

3.77 ± 6.73

7.74 ± 12.00*

< 0.0001

< 0.0001

0.044

NEFA (μmol/L)

509.81 ±192.78

575.03 ± 227.93*

589.47 ±230.07

646.75 ± 264.183

< 0.0001

< 0.0001

0.811

HOMA-IR

0.48 ± 0.53

0.94 ± 0.99*

1.28 ± 2.89

2.47 ± 4.49*

< 0.0001

< 0.0001

0.027

Adipo-IR

1.11 ± 1.22

2.57 ± 3.95*

2.10 ± 3.86

4.50 ± 5.24*

< 0.0001

< 0.0001

0.083

SBP (mmHg)

123.5 ± 15.3

126.2 ±15.1*

126.86 ± 16.86

130.44 ±18.20

0.007

0.001

0.701

DBP (mmHg)

76.2 ± 10.9

79.1 ± 10.6*

78.55 ± 11.49

82.45 ± 11.83*

< 0.0001

< 0.0001

0.530

AST (IU/L)

27.20 ±11.81

29.97 ± 11.41*

28.77 ±16.31

34.22 ± 18.71*

< 0.0001

0.004

0.163

ALT (IU/L)

25.28 ± 19.78

34.35 ± 20.64*

25.94 ± 20.91

40.70 ± 33.01*

< 0.0001

0.037

0.090

Cholesterol (mg/dl)

175.13 ± 31.00

184.24 ± 32.65*

173.98 ± 28.97

188.17 ± 34.57*

< 0.0001

0.548

0.274

Triglyceride (mg/dl)

104.78 ± 58.24

158.29 ± 115.18*

129.99 ± 111.28

163.97 ± 102.82*

< 0.0001

0.028

0.165

HDL-C (mg/dl)

53.75 ± 12.87

49.12 ± 11.55*

50.09 ± 10.67

48.30 ± 10.68

0.002

0.034

0.176

LDL-C (mg/dl)

115.27 ± 31.50

130.27 ± 32.97*

117.23 ± 28.96

129.08 ± 33.12*

< 0.0001

0.895

0.584

  1. *P < 0.025 = 0.05/2 (Bonferroni test, two sample comparison within the normal glucose tolerance and glucose intolerance groups).
  2. AFL indicates absence of fatty liver, FL indicates fatty liver. BMI indicates body mass index. SBP and DBP indicate systolic and diastolic blood pressure.
  3. NEFA indicates non-esterified fatty acid.