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Table 4 Distribution of the risk haplotypes

From: Polymorphisms in FGF12, VCL, CX43 and VAX1in Brazilian patients with nonsyndromic cleft lip with or without cleft palate

Tagging polymorphisms

Candidate risk haplotype*

Control group

CL ± P group

P value

CLO group

P value

CLP group

P value

FGF12

A-C-T

34.9%

35.5%

0.46

32.1%

0.73

37.2%

0.65

 rs11717284, rs6790664, rs1464942

FGF12

A-G-G

3.9%

2.7%

0.40

2.4%

0.77

2.9%

0.81

 rs1464942, rs12106855, rs1875753

VCL

C-A-T

53.5%

56.8%

0.44

58.3%

0.37

55.8%

0.59

 rs10762573, rs2131960, rs4746172

CX43

C-G

78.8%

77.6%

0.78

78.1%

0.89

77.4%

0.75

 rs12197797, rs11961755

VAX1

G-A-C

2.6%

6.7%

0.026

6.9%

0.19

6.7%

0.033

 rs10787760, rs6585429, rs1871345

  1. *Risk haplotypes of FGF12, VCL and CX43 were based on Jugessur et al. (2011).
  2. CL ± P: cleft lip with or without cleft palate, CLO: cleft lip only, CLP: cleft lip and palate.