Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children

da Silva, Carmela Farias; Zandoná, Marília Remuzzi; Vitolo, Márcia Regina; Campagnolo, Paula Dal Bó; Rotta, Liane Nanci; Almeida, Silvana; Mattevi, Vanessa Suñé

doi:10.1186/1471-2350-14-34

BMC Medical Genetics

Table 2 Mean anthropometric parameters and dietary patterns according to FTO genotypes in the São Leopoldo cohort

From: Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children

Phenotypes	T/T		T/A		A/A		P
	Mean ± SD	n	Mean ± SD	n	Mean ± SD	n
1 year
BMI Z-score	0.57 ± 1.05	129	0.55 ± 1.02	157	0.70 ± 1.22	56	0.615¹
Total energy intake (kcal/day)	946 ± 369	122	924 ± 422	144	891 ± 405	54	0.734²
Energy intake from lipids (kcal/day)	261 ± 120	122	255 ± 138	144	238 ± 142	54	0.567¹
Energy intake from carbohydrates (kcal/day)	528 ± 221	122	517 ± 240	144	507 ± 216	54	0.830¹
4 years
BMI Z-score	0.26 ± 1.19^6,7	125	0.13 ± 0.98⁶	154	0.57 ± 1.31⁷	54	0.036 ¹
Sum of skinfolds (mm)	13.4 ± 4.5	124	13.0 ± 3.6	152	15.0 ± 6.2	54	0.170^3,4
Waist circumference (cm)	51.6 ± 7.2	126	51.3 ± 7.4	156	52.8 ± 7.7	55	0.394¹
Total energy intake (kcal/day)	1562 ± 387	121	1469 ± 387	154	1483 ± 456	55	0.145¹
Energy intake from lipids (kcal/day)	462 ± 163⁸	121	410 ± 133⁹	154	416 ± 167^8,9	55	0.014 ¹
Energy intake from carbohydrates (kcal/day)	869 ± 235	121	838 ± 239	154	856 ± 264	55	0.557¹
BMI variation 1-4 years (%)	-9.20 ± 8.96	124	-9.97 ± 8.01	150	-7.46 ± 10.42	53	0.211⁵
8 years
BMI Z-score	0.48 ± 1.25^10,11	114	0.14 ± 1.35¹⁰	141	0.78 ± 1.60¹¹	49	0.011 ¹
Sum of skinfolds (mm)	17.7 ± 8.7	114	16.6 ± 7.0	142	22.2 ± 12.8	49	0.048 ^3,4
Waist circumference (cm)	57.0 ± 7.0	114	56.1 ± 5.5	142	59.5 ± 8.2	49	0.054⁴
Total energy intake (kcal/day)	1557 ± 374	113	1577 ± 347	141	1571 ± 480	49	0.911¹
Energy intake from lipids (kcal/day)	449 ± 155	113	457 ± 139	141	480 ± 202	49	0.495¹
Energy intake from carbohydrates (kcal/day)	890 ± 218	113	911 ± 206	141	871 ± 252	49	0.493¹
BMI variation 8-4 years (%)	6.96 ± 11.21	109	3.60 ± 10.63	136	8.70 ± 13.50	46	0.015 ⁵

Abbreviations: BMI, body mass index.
¹ Oneway ANOVA.
² General linear model including the covariate intervention group.
³ Ln-transformed variable.
⁴ Kruskal-Wallis test.
⁵ General linear model including the covariates gender, age variation between phase 1 y and phase 4 y and intervention group.
^6,7 Tukey test T/T x T/A P = 0.537; T/A x A/A P = 0.028; T/T x A/A P = 0.200.
^8,9 Tukey test T/T x T/A P = 0.013; T/A x A/A P = 0.958; T/T x A/A P = 0.151.
^10,11 Tukey test T/T x T/A P = 0.118; T/A x A/A P = 0.014; T/T x A/A P = 0.403.

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