Skip to main content

Table 5 Association between VDR polymorphisms and nevus number

From: Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona

  SNP Position* Change MAF% HWEP^ Genotype Cases <50(%) Cases >100(%) OR (95%CI)a P additive a OR (95%CI)b P additive b
1 rs7136534 48294626 C/T 0.18 0.400 C/C 101 (68.7) 70 (65.4) 1.00    
       T/C 40 (27.2) 33 (30.8) 1.15 (0.65- 2.02)    
       T/T 6 (4.1) 4 (3.7) 0.78 (0.21- 2.94)    
       additive    1.03 (0.65- 1.62) 0.903 1.18 (0.73- 1.92) 0.504
2 rs11574027 48287373 G/T 0.10 1.000 G/G 119 (82.1%) 86 (78.9%) 1.00    
       T/G 25 (17.2%) 23 (21.1%) 1.35 (0.71-2.57)    
       T/T 1 (0.7%) 0 (0%) NA    
       additive    1.19 (0.64- 2.21) 0.580 1.30 (0.67- 2.52) 0.431
3 rs11168287 48285414 G/A 0.44 0.869 G/G 43 (29.3) 36 (33.0) 1.00    
       A/G 72 (49.0) 57 (52.3) 0.99 (0.55- 1.76)    
       A/A 32 (21.8) 16 (14.7) 0.58 (0.27- 1.24)    
       additive    0.79 (0.55- 1.14) 0.212 0.83 (0.56- 1.23) 0.352
4 rs2238136 48277713 G/A 0.24 0.349 G/G 86 (60.1) 52 (52.5) 1.00    
       A/G 47 (32.9) 44 (44.4) 1.61 (0.93- 2.79)    
       A/A 10 (7.0) 3 (3.0) 0.47 (0.12- 1.82)    
       additive    1.11 (0.72- 1.72) 0.636 1.05 (0.66- 1.67) 0.845
5 rs3782905 48266167 C/G 0.36 0.483 C/C 52 (35.9) 42 (38.5) 1.00    
       C/G 74 (51.0) 63 (57.8) 1.07 (0.62- 1.83)    
       G/G 19 (13.1) 4 (3.7) 0.22 (0.07- 0.71)    
       additive    0.70 (0.46- 1.06) 0.134 0.69 (0.44- 1.08) 0.099
6 rs2189480 48263828 G/T 0.35 0.238 G/G **    0.21 (0.07- 0.66)    
       G/G 65 (45.5) 30 (28.6) 1.00    
       T/G 68 (47.6) 63 (60.0) 1.92 (1.09- 3.39)    
       T/T 10 (7.0) 12 (11.4) 2.97 (1.12- 7.87)    
       additive    1.80 (1.17- 2.76) 0.006 1.66 (1.05- 2.60) 0.027
7 rs2239179 48257766 A/G 0.44 0.192 A/A 35 (23.5) 36 (33.3) 1.00    
       A/G 83 (55.7) 58 (53.7) 0.70 (0.39- 1.26)    
       G/G 31 (20.8) 14 (13.0) 0.44 (0.20- 0.99)    
       additive    0.67 (0.46- 0.99) 0.044 0.67 (0.44- 1.02) 0.060
8 rs11574077 48252927 T/C 0.05 0.463 T/T 129(87.8) 104 (93.7) 1.00    
       T/C 17 (11.6) 7 (6.3) 0.54 (0.21- 1.38)    
       C/C 1 (0.7) 0 (0.0) NA    
       additive    0.52 (0.21- 1.27) 0.135 0.45 (0.17- 1.18) 0.088
9 rs11168267 48251542 C/T 0.07 1.000 C/C 128(85.9) 98 (88.3) 1.00    
       T/C 21 (14.1) 12 (10.8) 0.68 (0.32- 1.48)    
       T/T 0 (0.0) 1 (0.9) NA    
       additive    0.84 (0.41- 1.72) 0.626 0.84 (0.38- 1.84) 0.656
10 rs7975128 48245828 G/A 0.33 0.385 G/G 56 (38.6) 63 (58.9) 1.00    
       A/G 64 (44.1) 35 (32.7) 0.47 (0.27- 0.82)    
       A/A 25 (17.2) 9 (8.4) 0.29 (0.12- 0.69)    
       additive    0.51 (0.35- 0.76) 0.0005 0.58 (0.38- 0.87) 0.007
  1. MAF minor allele frequency.
  2. *SNP position from NCBI; ^ HWE Hardy –Weinberg Equilibrium for cases with low number of nevi (cases <50) as reference group; a = adjusted for age and gender; b = adjusted for age. gender and number of melanoma.
  3. ** recessive model for SNP rs3782905.