Table 5 Association between VDR polymorphisms and nevus number
SNP | Position* | Change | MAF% | HWEP^ | Genotype | Cases <50(%) | Cases >100(%) | OR (95%CI)a | P additive a | OR (95%CI)b | P additive b | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | rs7136534 | 48294626 | C/T | 0.18 | 0.400 | C/C | 101 (68.7) | 70 (65.4) | 1.00 | |||
T/C | 40 (27.2) | 33 (30.8) | 1.15 (0.65- 2.02) | |||||||||
T/T | 6 (4.1) | 4 (3.7) | 0.78 (0.21- 2.94) | |||||||||
additive | 1.03 (0.65- 1.62) | 0.903 | 1.18 (0.73- 1.92) | 0.504 | ||||||||
2 | rs11574027 | 48287373 | G/T | 0.10 | 1.000 | G/G | 119 (82.1%) | 86 (78.9%) | 1.00 | |||
T/G | 25 (17.2%) | 23 (21.1%) | 1.35 (0.71-2.57) | |||||||||
T/T | 1 (0.7%) | 0 (0%) | NA | |||||||||
additive | 1.19 (0.64- 2.21) | 0.580 | 1.30 (0.67- 2.52) | 0.431 | ||||||||
3 | rs11168287 | 48285414 | G/A | 0.44 | 0.869 | G/G | 43 (29.3) | 36 (33.0) | 1.00 | |||
A/G | 72 (49.0) | 57 (52.3) | 0.99 (0.55- 1.76) | |||||||||
A/A | 32 (21.8) | 16 (14.7) | 0.58 (0.27- 1.24) | |||||||||
additive | 0.79 (0.55- 1.14) | 0.212 | 0.83 (0.56- 1.23) | 0.352 | ||||||||
4 | rs2238136 | 48277713 | G/A | 0.24 | 0.349 | G/G | 86 (60.1) | 52 (52.5) | 1.00 | |||
A/G | 47 (32.9) | 44 (44.4) | 1.61 (0.93- 2.79) | |||||||||
A/A | 10 (7.0) | 3 (3.0) | 0.47 (0.12- 1.82) | |||||||||
additive | 1.11 (0.72- 1.72) | 0.636 | 1.05 (0.66- 1.67) | 0.845 | ||||||||
5 | rs3782905 | 48266167 | C/G | 0.36 | 0.483 | C/C | 52 (35.9) | 42 (38.5) | 1.00 | |||
C/G | 74 (51.0) | 63 (57.8) | 1.07 (0.62- 1.83) | |||||||||
G/G | 19 (13.1) | 4 (3.7) | 0.22 (0.07- 0.71) | |||||||||
additive | 0.70 (0.46- 1.06) | 0.134 | 0.69 (0.44- 1.08) | 0.099 | ||||||||
6 | rs2189480 | 48263828 | G/T | 0.35 | 0.238 | G/G ** | 0.21 (0.07- 0.66) | |||||
G/G | 65 (45.5) | 30 (28.6) | 1.00 | |||||||||
T/G | 68 (47.6) | 63 (60.0) | 1.92 (1.09- 3.39) | |||||||||
T/T | 10 (7.0) | 12 (11.4) | 2.97 (1.12- 7.87) | |||||||||
additive | 1.80 (1.17- 2.76) | 0.006 | 1.66 (1.05- 2.60) | 0.027 | ||||||||
7 | rs2239179 | 48257766 | A/G | 0.44 | 0.192 | A/A | 35 (23.5) | 36 (33.3) | 1.00 | |||
A/G | 83 (55.7) | 58 (53.7) | 0.70 (0.39- 1.26) | |||||||||
G/G | 31 (20.8) | 14 (13.0) | 0.44 (0.20- 0.99) | |||||||||
additive | 0.67 (0.46- 0.99) | 0.044 | 0.67 (0.44- 1.02) | 0.060 | ||||||||
8 | rs11574077 | 48252927 | T/C | 0.05 | 0.463 | T/T | 129(87.8) | 104 (93.7) | 1.00 | |||
T/C | 17 (11.6) | 7 (6.3) | 0.54 (0.21- 1.38) | |||||||||
C/C | 1 (0.7) | 0 (0.0) | NA | |||||||||
additive | 0.52 (0.21- 1.27) | 0.135 | 0.45 (0.17- 1.18) | 0.088 | ||||||||
9 | rs11168267 | 48251542 | C/T | 0.07 | 1.000 | C/C | 128(85.9) | 98 (88.3) | 1.00 | |||
T/C | 21 (14.1) | 12 (10.8) | 0.68 (0.32- 1.48) | |||||||||
T/T | 0 (0.0) | 1 (0.9) | NA | |||||||||
additive | 0.84 (0.41- 1.72) | 0.626 | 0.84 (0.38- 1.84) | 0.656 | ||||||||
10 | rs7975128 | 48245828 | G/A | 0.33 | 0.385 | G/G | 56 (38.6) | 63 (58.9) | 1.00 | |||
A/G | 64 (44.1) | 35 (32.7) | 0.47 (0.27- 0.82) | |||||||||
A/A | 25 (17.2) | 9 (8.4) | 0.29 (0.12- 0.69) | |||||||||
additive | 0.51 (0.35- 0.76) | 0.0005 | 0.58 (0.38- 0.87) | 0.007 |