Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4Rgenes to obesity in Mexican children

Table 3 Association between SNPs MC4R rs17782313, NEGR1 rs2815752, ENPP1 rs7754561, NPC1 rs1805081, GNPDA2 rs10938397 and FTO rs1421085, and metabolic quantitative traits in 1,171 nonobese Mexican children

		BMI	Fasting serum insulin		Fasting plasma glucose		Total cholesterol		Triglycerides
Locus SNP RA*	β(SE)	P	β(SE)	P	β(SE)	P	β(SE)	P	β(SE)	P
*NEGR1 r* s2815752 A	0.24	0.019	0.01	0.611	0.07	0.353	2.14	0.139	0.01	0.425
*NEGR1 r* s2815752 A	(0.10)		(0.03)		(0.07)		(1.44)		(0.02)
*NPC1* rs1805081 A	−0.16	0.126	−0.10	1.21 × 10 ^-3	−0.08	0.278	2.22	0.144	−0.003	0.884
*NPC1* rs1805081 A	(0.11)		(0.03)		(0.07)		(1.52)		(0.02)
*ENPP1* rs7754561 G	−0.11	0.209	0.004	0.873	0.01	0.905	2.20	0.087	0.004	0.827
*ENPP1* rs7754561 G	(0.09)		(0.03)		(0.06)		(1.29)		(0.02)
*MCR4* rs17782313 C	0.41	0.012	0.04	0.362	0.36	1.47 × 10 ^-3	2.71	0.247	0.02	0.410
*MCR4* rs17782313 C	(0.16)		(0.05)		(0.11)		(2.34)		(0.03)
*GNPDA2* rs10938397 G	0.10	0.288	0.04	0.126	0.10	0.132	1.90	0.176	0.03	0.076
*GNPDA2* rs10938397 G	(0.10)		(0.03)		(0.07)		(1.40)		(0.02)
*FTO* rs1421085 C	−0.17	0.171	−0.06	0.064	−0.14	0.111	3.70	0.032	0.006	0.778
*FTO* rs1421085 C	(0.12)		(0.04)		(0.09)		(1.72)		(0.02)

Data for fasting serum insulin and triglycerides were logarithmically transformed before statistical analysis. Units are: BMI in kg/m², fasting serum insulin in μU/mL, fasting plasma glucose in mmol/L, total cholesterol in mg/dL and triglycerides in mg/dL.
*We noted the risk-alleles reported in European populations.
RA, risk-allele; SE, standard error; β, effect-size; P, P-value; BMI, body mass index.

ISSN: 1471-2350