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Table 3 Association between SNPs MC4R rs17782313, NEGR1 rs2815752, ENPP1 rs7754561, NPC1 rs1805081, GNPDA2 rs10938397 and FTO rs1421085, and metabolic quantitative traits in 1,171 nonobese Mexican children

From: Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4Rgenes to obesity in Mexican children

   BMI Fasting serum insulin Fasting plasma glucose Total cholesterol Triglycerides
Locus SNP RA* β(SE) P β(SE) P β(SE) P β(SE) P β(SE) P
NEGR1 r s2815752 A 0.24 0.019 0.01 0.611 0.07 0.353 2.14 0.139 0.01 0.425
(0.10)   (0.03)   (0.07)   (1.44)   (0.02)  
NPC1 rs1805081 A −0.16 0.126 −0.10 1.21 × 10 -3 −0.08 0.278 2.22 0.144 −0.003 0.884
(0.11)   (0.03)   (0.07)   (1.52)   (0.02)  
ENPP1 rs7754561 G −0.11 0.209 0.004 0.873 0.01 0.905 2.20 0.087 0.004 0.827
(0.09)   (0.03)   (0.06)   (1.29)   (0.02)  
MCR4 rs17782313 C 0.41 0.012 0.04 0.362 0.36 1.47 × 10 -3 2.71 0.247 0.02 0.410
(0.16)   (0.05)   (0.11)   (2.34)   (0.03)  
GNPDA2 rs10938397 G 0.10 0.288 0.04 0.126 0.10 0.132 1.90 0.176 0.03 0.076
(0.10)   (0.03)   (0.07)   (1.40)   (0.02)  
FTO rs1421085 C −0.17 0.171 −0.06 0.064 −0.14 0.111 3.70 0.032 0.006 0.778
(0.12)   (0.04)   (0.09)   (1.72)   (0.02)  
  1. Data for fasting serum insulin and triglycerides were logarithmically transformed before statistical analysis. Units are: BMI in kg/m2, fasting serum insulin in μU/mL, fasting plasma glucose in mmol/L, total cholesterol in mg/dL and triglycerides in mg/dL.
  2. *We noted the risk-alleles reported in European populations.
  3. RA, risk-allele; SE, standard error; β, effect-size; P, P-value; BMI, body mass index.