Skip to main content

Table 3 Meta-analysis of the association between ADIPOQ haplotypes and serum adiponectin in our combined cohort of 3,431 individuals

From: A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome

Block

Haplotype and copy number

β (95% CI)

P-value

P-value (heterogeneity)

1

AAAG

   
 

1

0.001 (−0.041, 0.043)

0.96

0.67

 

2

0.081 (0.026, 0.135)

3.70E-03

0.74

 

GACG

   
 

1

−0.071 (−0.110, -0.032)

4.00E-04

0.79

 

2

−0.109 (−0.183, -0.035)

3.70E-03

0.61

 

GAAT

   
 

1

−0.047 (−0.089, -0.005)

3.00E-02

0.62

 

2

0.026 (−0.099, 0.152)

0.68

0.85

 

GAAG

   
 

1

0.219 (0.142, 0.296)

2.55E-08

0.11

 

2

0.280 (0.070, 0.490)

9.20E-03

0.89

 

GGCG

   
 

1

−0.152 (−0.231, -0.092)

8.22E-07

0.28

 

2

0.051 (−0.188, 0.291)

0.67

0.60

2

TCCTAAT

   
 

1

0.007 (−0.036, 0.049)

0.76

0.34

 

2

0.052 (−0.048, 0.153)

0.31

0.08

 

TCCTAAG

   
 

1

−0.069 (−0.108, 0.030)

6.00E-04

0.54

 

2

−0.115 (−0.183, -0.046)

1.00E-03

0.64

 

TTCCCGG

   
 

1

0.026 (−0.021, 0.073)

0.28

0.73

 

2

0.122 (−0.035, 0.278)

0.13

0.96

 

CCATCAG

   
 

1

0.244 (0.183, 0.305)

5.11E-15

0.29

 

2

0.301 (0.079, 0.523)

7.80E-03

0.88

 

TCCTCAG

   
 

1

−0.156 (−0.228, -0.084)

2.42E-05

0.22

 

2

−0.402 (−0.066, -0.146)

2.10E-03

0.74

 

TCCCCGG

   
 

1

−0.067 (−0.129, -0.006)

3.11E-02

0.37

 

2

0.088 (−0.217, 0.393)

0.57

0.45

3

TCGCG

   
 

1

−0.030 (−0.081, 0.022)

0.25

0.34

 

2

−0.044 (−0.096, 0.008)

0.09

0.44

 

TTACA

   
 

1

0.071 (0.032, 0.111)

4.00E-04

0.57

 

2

0.190 (0.114, 0.267)

1.01E-06

0.88

 

GTATG

   
 

1

0.022 (−0.049, 0.094)

0.54

0.12

 

2

0.220 (−0.207, 0.647)

0.31

0.001

 

TTGCG

   
 

1

−0.232 (−0.297, -0.167)

2.87E-12

0.31

 

2

−0.186 (−0.597, 0.225)

0.38

0.14

  1. Block 1: rs10937273-rs12637534-rs1648707-rs864265.
  2. Block 2: rs822387-rs860291-rs16861209-rs822391-rs822395-rs822396-rs12495941.
  3. Block 3: rs2241766-rs3821799-rs3774261-rs1063537-rs6444175.