|
Variant
|
Controls
|
Cases
|
Uncorr. B.(95% CI)
|
Uncorr. P-value
|
Corr. B.(95% C.I.)
|
Corr. P-value
|
|---|
|
Hypertension
| | | | | | |
|
rs2241766 (TG + GG)
|
0.844
|
0.855
|
1.25(1.01–1.56)
|
0.039*
|
1.35(1.01–1.72)
|
0.015*
|
|
rs9842733 T
|
0.019
|
0.028
|
1.44(1.03–2.01)
|
0.031*
|
1.48(1.01–2.07)
|
0.042*
|
|
Myocardial Infarction
| | | | | |
|
rs1063537 T
|
0.165
|
0.186
|
1.16(1.04–1.30)
|
0.010**
|
1.16(1.04–1.30)
|
0.070
|
|
rs2082940 T
|
0.206
|
0.225
|
1.12(1.01–1.24)
|
0.035*
|
1.11(0.98–1.26)
|
0.102
|
|
rs1063539 C
|
0.176
|
0.194
|
1.13(1.01–1.20)
|
0.035*
|
1.13(1.01–1.20
|
0.091
|
|
Hypercholestrolaemia
| | | | | |
|
rs9842733 T
|
0.023
|
0.030
|
1.32(1.01–1.72)
|
0.043*
|
1.38(0.97–1.69)
|
0.085
|
|
Low HDL-Cholesterol
| | | | | |
|
rs6444174 (TC + CC)
|
0.848
|
0.855
|
1.23(1.08–1.49)
|
0.042*
|
1.28(1.05–1.59)
|
0.016*
|
|
rs2241766 (TG + GG)
|
0.847
|
0.858
|
1.32(1.06–1.59)
|
0.013*
|
1.35(1.10–1.67)
|
0.005***
|
|
Obesity
| | | | | | |
|
rs2241766 (TG + GG)
|
0.848
|
0.858
|
1.27(0.96–1.54)
|
0.028*
|
1.61(0.99–1.54)
|
0.67
|
- The table lists the variants associated with the hypertension (3541 cases vs 1101 controls), myocardial infarction (3005 vs 1640), obesity (1589 vs 2472), hypercholesterolaemia (2441 vs 2019) and low high density lipoprotein (1762 vs 2156) among the 4646 studied individuals before and following adjustments for the influences of other risks factors. Bonferroni corrections for age, sex and family history was performed for all studied variables, while inclusion of the individual disease traits into the multivariate analysis varied dependent on the primary study case group. B, Coefficient; C.I., confidence interval; Uncorr. P-value; uncorrected P-value; Corr. P-value; the adjusted P-values for the associations in presence of other factors. *P < 0.05, **P < 0.01, ***P < 0.005 by χ2 test.
