The 3′-UTR of the adiponectin Q gene harbours susceptibility loci for atherosclerosis and its metabolic risk traits

Table 2 Adiponectin Q genotyping in cardiovascular disease traits in the general population

Variant	Controls	Cases	Uncorr. B.(95% CI)	Uncorr. P-value	Corr. B.(95% C.I.)	Corr. P-value
Hypertension
rs2241766 (TG + GG)	0.844	0.855	1.25(1.01–1.56)	0.039*	1.35(1.01–1.72)	0.015*
rs9842733 T	0.019	0.028	1.44(1.03–2.01)	0.031*	1.48(1.01–2.07)	0.042*
Myocardial Infarction
rs1063537 T	0.165	0.186	1.16(1.04–1.30)	0.010**	1.16(1.04–1.30)	0.070
rs2082940 T	0.206	0.225	1.12(1.01–1.24)	0.035*	1.11(0.98–1.26)	0.102
rs1063539 C	0.176	0.194	1.13(1.01–1.20)	0.035*	1.13(1.01–1.20	0.091
Hypercholestrolaemia
rs9842733 T	0.023	0.030	1.32(1.01–1.72)	0.043*	1.38(0.97–1.69)	0.085
Low HDL-Cholesterol
rs6444174 (TC + CC)	0.848	0.855	1.23(1.08–1.49)	0.042*	1.28(1.05–1.59)	0.016*
rs2241766 (TG + GG)	0.847	0.858	1.32(1.06–1.59)	0.013*	1.35(1.10–1.67)	0.005***
Obesity
rs2241766 (TG + GG)	0.848	0.858	1.27(0.96–1.54)	0.028*	1.61(0.99–1.54)	0.67

The table lists the variants associated with the hypertension (3541 cases vs 1101 controls), myocardial infarction (3005 vs 1640), obesity (1589 vs 2472), hypercholesterolaemia (2441 vs 2019) and low high density lipoprotein (1762 vs 2156) among the 4646 studied individuals before and following adjustments for the influences of other risks factors. Bonferroni corrections for age, sex and family history was performed for all studied variables, while inclusion of the individual disease traits into the multivariate analysis varied dependent on the primary study case group. B, Coefficient; C.I., confidence interval; Uncorr. P-value; uncorrected P-value; Corr. P-value; the adjusted P-values for the associations in presence of other factors. *P < 0.05, **P < 0.01, ***P < 0.005 by χ² test.

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