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Table 2 Clinical characteristics of UK families

From: Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

  Pedigrees Sibling 1 Sibling 2
Age (mean years), ±SD 26.2 ± 1.6 13.3 ± 4.4 10.3 ± 4.6
Gender (% female) 50.8 54.6 53.7
Asthma (%, doctor diagnosed) 61.6 100 100
FEV1 (% predicted, ±SD) ND 95.4 ± 15.6 96.2 ± 14.9
Positive skin prick test (%) 62.5 73.9 65.1
Log total serum IgE (mean ± SD) 2.04 ± 0.7 2.33 ± 0.7 2.33 ± 0.7
Eczema (%, questionnaire) 41.1 53.5 55.1
Hay fever (%, questionnaire) 50.2 64.9 47.4
BTS (%) step 1 19.1 24.9 23.8
• Step 2 32.5 52.7 55.7
• Step 3 6.1 11.6 10.2
• Step 4 1.8 4.6 1.4
• Step 5 2.9 4.6 5.3
PC20 (4 mg/ml,%)   46.9 59.9
n 1578 370 361
  1. The recruitment and clinical characterisation of these subjects has been extensively described elsewhere [15]. PC20 (4 mg/ml, %) only available in Southampton families.