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Table 2 Results of overall and stratified analyses for the association of XRCC1 399 G → A and risk of glioma, all eligible studies

From: Association between XRCC1polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis

Stratification factor No. of studies I 2(%) Odds ratio 95% Confidence interval P value
Overall 6 87 1.17 1.05-1.30 0.006
Gender      
 Male 1 NA 0.94 0.62-1.44 0.78
 Female 1 NA 2.27 1.45-3.57 < 0.001
Glioma Subtype
 Grade III 2 0 1.05 0.89-1.25 0.56
 Grade IV 2 46 1.20 0.97-1.47 0.09
Sample size
 < 500 2 92 3.09 2.06-4.65 < 0.001
 ≥ 500 4 0 1.08 0.96-1.21 0.19
Country
 US 3 8 1.11 0.94-1.31 0.22
 Other 3 94 1.22 1.05-1.42 0.009
Genotyping method
 PCR-RFLP 4 92 1.16 1.01-1.32 0.03
 Other 2 0 1.19 0.97-1.46 0.09