 
Case control set

Family set


 
Freq. (n = 1914)

FLG (n = 1914)

NONFLG (n = 1605)

FLG (268 families)

NONFLG (162 families)


Haplotypes

Cases

Controls

OR

p value

OR

p value

Freq.

T:U

OR

p value

T:U

OR

p value


2222

2222

0.3656

0.4028

0.83

1.05 E02

1.07

4.10E01

0.3992

206.3:256.1

0.81

2.08 E02

138.6:152.4

0.91

4.18 E01

2222

2212

0.0102

0.0035

4.92

2.67 E03
  
0.0039

2.0:6.0

0.33

1.58 E01
   
2222

2221

0.0052

0.0062

0.80

6.50 E01
  
0.0011

2.1:0.1

38.89

1.66 E01
   
2222

2122

0.0030

0.0041

0.63

4.80 E01
  
NA

NA

NA

NA
   
2222

Total

0.3841

0.4166

0.85

2.43 E02
  
0.4042

210.4:262.1

0.80

1.74 E02
   
2212

2222

0.1180

0.1392

0.78

2.43 E02

0.95

6.34E01

0.1077

110.6:91.8

1.20

1.86 E01

66.5:59.6

1.11

5.42 E01

2212

2212

0.0014

0.0018

0.53

6.35 E01
  
NA

NA

NA

NA
   
2212

2221

0.0010

0.0012

0.63

7.79 E01
  
0.0011

1.1:1.1

1.00

1.00 E+00
   
2212

Total

0.1204

0.1422

0.76

1.28 E02
  
0.1088

111.7:92.9

1.20

1.89 E01
   
2122

2222

0.1289

0.1488

0.81

4.78 E02

0.90

3.44E01

0.1205

93.7:126.6

0.74

2.66 E02

64.1:79.9

0.80

1.87 E01

2122

2221

0.0241

0.0032

12.65

1.75 E10
  
0.0267

35.2:18.3

1.92

2.07 E02
   
2122

2212

0.0123

0.0037

7.00

1.21 E04
  
0.0068

7.0:8.0

0.87

7.91 E01
   
2122

2122

0.0114

0.0012

22.62

7.16 E07
  
0.0115

15.0:9.0

1.67

2.21 E01
   
2122

2211

0.0034

0.0000

NA

NA
  
NA

NA

NA

NA
   
2122

Total

0.1800

0.1569

1.23

2.69 E02
  
0.1655

150.9:161.9

0.93

5.34 E01
   
2121

2212

0.0448

0.0028

31.26

3.10 E24
  
0.0538

74.0:38.0

1.95

6.61 E04
   
2121

2222

0.0267

0.0295

0.88

5.63 E01

0.97

8.94E01

0.0123

11.8:13.8

0.85

6.92 E01

5.7:9.7

0.59

3.08 E01

2121

2221

0.0075

0.0000

NA

NA
  
0.0019

2.0:2.0

1.00

1.00 E+00
   
2121

Total

0.0790

0.0322

2.65

5.22 E10
  
0.0680

87.7:53.7

1.63

4.22 E03
   
2112

2222

0.0562

0.0892

0.49

2.43 E06

0.59

8.22E04

0.0582

46.8:68.0

0.69

4.73 E02

24.2:36.3

0.67

1.19 E01

2112

2212

0.0041

0.0016

6.23

4.20 E02
  
0.0048

4.0:6.0

0.67

5.27 E01
   
2112

2221

0.0015

0.0010

2.59

4.73 E01
  
0.0029

2.1:3.0

0.69

6.75 E01
   
2112

Total

0.0618

0.0917

0.60

3.89 E04
  
0.0659

52.8:77.1

0.69

3.37 E02
   
1222

2222

0.0982

0.0785

1.36

1.69 E02

1.71

5.55E05

0.1186

124.8:88.6

1.41

1.30 E02

92.0:54.9

1.68

2.19 E03

1222

1222

0.0061

0.0010

8.05

2.77 E03
  
NA

NA

NA

NA
   
1222

Total

0.1043

0.0795

1.42

4.81 E03
  
0.1186

124.8:88.6

1.41

1.30 E02
   
 Logistic regression was used for testing a single haplotype for the case control set and the weighted TDT statistic was used for a single haplotype by computing transmitted (T) versus nontransmitted (U) haplotypes. Calculations were carried out for the full set (FLG) and the FLG reduced sets (NONFLG). The minor allele was coded as 1 and the major one as 2. For the sake of following the rare FLG mutations the frequency threshold for the 8SNP haplotype estimation had been lowered to 0.001, however, only combined with best pattern haplotypes down to a total frequency > 0.05 in the full case set.
 Abbreviations are as follows: Freq., haplotype frequency; OR, odds ratio; FLG, Filaggrin gene; T:U, transmitted:nontransmitted; NA, not available.