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Table 1 Resulting ten best haplotype patterns after replication of the multi-locus stepwise regression.

From: Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis

No. SNP 1 SNP 2 SNP 3 SNP 4 MSR
p value
MSR
p value
(corrected)
TDT
p value
TDT
p value
(corrected)
1 rs7550106 rs499697 rs17659389 rs17670505 1.30 × 10-13 4.13 × 10-7 0.00013 0.03976
2 rs499697 rs17670505 rs576941 rs16835086 2.99 × 10-10 9.54 × 10-4 0.00033 0.09809
3 rs13373771 rs499697 rs6702463 rs17670505 9.85 × 10-10 3.14 × 10-3 0.00034 0.10260
4 rs6678672 rs4845766 rs499697 rs17659389 9.70 × 10-10 3.10 × 10-3 0.00040 0.11999
5 rs6678672 rs4845766 rs13373771 rs17659389 1.05 × 10-09 3.34 × 10-3 0.00051 0.15153
6 rs7550106 rs499697 rs989834 rs17670505 4.20 × 10-10 1.34 × 10-3 0.00053 0.15796
7 rs11204897 rs13373771 rs6701221 rs17670505 2.51 × 10-10 8.01 × 10-4 0.00055 0.16504
8 rs499697 rs17659389 rs17670505 rs16835086 4.77 × 10-10 1.52 × 10-3 0.00058 0.17369
9 rs2999547 rs499697 rs17659389 rs17670505 1.65 × 10-10 5.25 × 10-4 0.00061 0.18254
10 rs13373771 rs1923508 rs6701221 rs17670505 7.36 × 10-10 2.35 × 10-3 0.00074 0.22309
  1. Multi-locus stepwise regression (MSR p value) was used for case control set (n = 1,914) and replicated in family set (268 families) using the weighted TDT statistic. Bonferroni corrections were done by multiplying 3188010 to the MSR p value and 300 to the TDT p value. Only the first haplotype pattern kept significant after Bonferroni correction.