Table 5 Clinical findings stratified by SNPs in the whole group of patients
FPN1 -8CG | Onset | Duration | EDSS | PI | MSSS |
|---|---|---|---|---|---|
−8CC | 33.5±9.8 | 9.3±7.35 | 2.73±2.07 | 0.58±0.78 | 3.72±2.66 |
(n=244) | (11.0-60.0) | (0.3-38.0) | (1.0-10) | (0.03-7.0) | (0.13-9.99) |
−8CG | 31.92±10.45 | 9.32±7.95 | 3.07±2.48 | 0.64±1.24 | 4.09±2.78 |
(n=141) | (14.0-61.0) | (0.2-50.0) | (1.0-9.0) | (0.03-10) | (0.15-9.97) |
−8GG | 33.38±12.3 | 7.0±5.17 | 3.59±2.43 | 1.11±2.01 | 5.08±2.98 |
(n=29) | (15.0-53.0) | (0.2-20.4) | (1.0-9.0) | (0.1-10.0) | (0.78-9.97) |
P uncorrected | NS | 0.05 | 0.045 | 0.01 | 0.01 |
(P corrected) | (0.05) | (0.05) | |||
HFE C282Y | |||||
282CC | 32.3±10.37 | 9.19±7.49 | 2.9±2.25 | 0.63±1.07 | 3.9±2.73 |
(n=401) | (11.0-60.0) | (0.2-50.0) | (1.0-10) | (0.03-10.0) | (0.13-9.99) |
282CY | 33.62±11.12 | 7.27±5.35 | 3.16±2.21 | 0.58±1.54 | 4.64±2.91 |
(n=13) | (16.0-61.0) | (1.0-27.0) | (1.0-9.0) | (0.13-1.3) | (1.13-9.92) |
P-value | NS | NS | NS | NS | NS |
HFE H63D | |||||
63HH | 32.75±10.94 | 8.92±7.12 | 2.89±2.23 | 0.62±0.98 | 3.99±2.78 |
(n=288) | (11.0-61.0) | (0.2-50.0) | (1.0-10) | (0.03-10) | (0.15-9.99) |
63HD | 30.97±8.94 | 9.8±8.2 | 2.81±2.21 | 0.55±1.01 | 3.65±2.55 |
(n=113) | (14.0-56.0) | (0.5-38.0) | (1.0-9.0) | (0.03-10) | (0.13-9.97) |
63DD | 36.1±8.23 | 8.43±7.57 | 3.96±2.93 | 1.63±2.6 | 5.33±3.03 |
(n=13) | (28.0-55.0) | (0.2-22.2) | (1.0-8.5) | (0.2-7.5) | (1.28-9.99) |
P uncorrected | 0.06 | NS | NS | 0.009 | 0.03 |
(P corrected) | (NS) | (0.045) | (NS) | ||
HEPC -582AG | |||||
−582AA | 29.57±9.86 | 9.54-7.3 | 2.59±2.06 | 0.57±.1.14 | 3.39±2.56 |
(n=205) | (14.0-61.0) | (0.2-38.0) | (1.0-9.0) | (0.03-10) | (0.13-9.97) |
−582AG | 35.1±9.92 | 8.78±7.78 | 3.01±2.22 | 0.63±0.94 | 4.26±2.7 |
(n=175) | (11.0-56.0) | (0.2-50.0) | (1.0-9.0) | (0.04-10.0) | (0.29-9.98) |
−582GG | 35.2±11.56 | 8.55±6.45 | 4.24±2.87 | 0.96±1.38 | 5.6±3.06 |
(n=34) | (20.0-56.0) | (0.5-27.0) | (1.0-10) | (0.13-7.0) | (1.13-9.99) |
P uncorrected | 0.07* | NS | 0.003 | 0.08 | 0.001 |
(P corrected) | (NS) | (0.015) | (NS) | (0.005) | |
TF P570S | |||||
570PP | 32.38±10.44 | 8.42±6.97 | 2.72±2.15 | 0.69±1.26 | 3.78±2.66 |
(n=278) | (11.0-56.0) | (0.2 34.0) | (1.0-10) | (0.03-10.0) | (0.15-9.99) |
570PS | 32.32±10.53 | 11.08±8.24 | 3.38±2.41 | 0.48±0.52 | 4.28±2.92 |
(n=122) | (14.0-61.0) | (0.5-50.0) | (1.0-9.0) | (0.03-4.0) | (0.13-9.97) |
570SS | 32.53±8.43 | 6.52±6.17 | 2.47±2.05 | 0.77±0.89 | 4.1±2.52 |
(n=14) | (21.0-51.0) | (0.5-22.0) | (1.0-9.0) | (0.15-3.0) | (1.13-9.73) |
P uncorrected | NS | 0.06 | NS | NS | NS |
(P corrected) | (NS) |