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Table 1 Logistic regression top scoring SNPs, approach I

From: Data mining of high density genomic variant data for prediction of Alzheimer's disease risk

Gene Symbol dbSNP RS ID

Distance to Gene

Unadj. p-value

FDR_BH p-value

OR (95% CI)

Pathway/Disease/function

NISCHrs6784615

intron

7.16E-07

4.47E-02

2.21 (1.61-3.02)

Interaction with PAK4 for reduction of LIMK1 phosphorylation;

neuronal migration and axon/dendrite outgrowth [22, 23].

RABEP1rs4356530

upstream 27742

8.59E-07

4.47E-02

2.21 (1.61-3.02)

Endocytosis [24, 32].

THEMISrs9398855

intron

2.25E-06

8.78E-02

2.13 (1.56-2.92)

Immnune response [2527].

NDUFA12

rs249153

downstream 40719

4.13E-06

1.29E-01

1.62 (1.32-2.00)

AD, Parkinson's, Hungtinton's, oxidative phosphorylation [2832].

MUC21rs2517509

downstream 72544

4.93E-06

1.39E-01

3.14 (1.92-5.12)

Prevention of cell-cell interaction of Integrins [55].

TUSC1rs10115381

upstream 328744

5.33E-06

1.39E-01

2.08 (1.52-2.85)

Shwachman-Diamond syndrome [56].

CTNNA3rs10996618

downstream 187123

1.19E-05

2.03E-01

2.03 (1.48-2.78)

AD (4 studies), Adherens junction, Inmune response [10, 32].

  1. FDR_BH = Benjamini & Hochberg (1995) step-up False Discovery Rate control.