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Table 1 Logistic regression top scoring SNPs, approach I

From: Data mining of high density genomic variant data for prediction of Alzheimer's disease risk

Gene Symbol dbSNP RS ID Distance to Gene Unadj. p-value FDR_BH p-value OR (95% CI) Pathway/Disease/function
NISCHrs6784615 intron 7.16E-07 4.47E-02 2.21 (1.61-3.02) Interaction with PAK4 for reduction of LIMK1 phosphorylation;
neuronal migration and axon/dendrite outgrowth [22, 23].
RABEP1rs4356530 upstream 27742 8.59E-07 4.47E-02 2.21 (1.61-3.02) Endocytosis [24, 32].
THEMISrs9398855 intron 2.25E-06 8.78E-02 2.13 (1.56-2.92) Immnune response [2527].
NDUFA12
rs249153
downstream 40719 4.13E-06 1.29E-01 1.62 (1.32-2.00) AD, Parkinson's, Hungtinton's, oxidative phosphorylation [2832].
MUC21rs2517509 downstream 72544 4.93E-06 1.39E-01 3.14 (1.92-5.12) Prevention of cell-cell interaction of Integrins [55].
TUSC1rs10115381 upstream 328744 5.33E-06 1.39E-01 2.08 (1.52-2.85) Shwachman-Diamond syndrome [56].
CTNNA3rs10996618 downstream 187123 1.19E-05 2.03E-01 2.03 (1.48-2.78) AD (4 studies), Adherens junction, Inmune response [10, 32].
  1. FDR_BH = Benjamini & Hochberg (1995) step-up False Discovery Rate control.