Markers & haplotypes* | Haplotype counts | Haplotype being considered | All other haplotypes | Fisher's exact test | ||||
---|---|---|---|---|---|---|---|---|
Total no.† | no. in cluster (%) | Controls† | Cases† | Controls | Cases | Pvalue‡ | OR (95% CI) § | |
Sample Set 1 for cases defined by SE ≤-12 diopters Marker = rs220168 (S47), Cluster = 0.G | ||||||||
Markers: S47 | ||||||||
G (2) | 202 | 28 (13.9%) | 155 | 47 | 557 | 135 | 0.2744 | 1.25 (0.83 - 1.85) |
Markers: S47-S48 | ||||||||
GC (21) | 35 | 26 (74.3%) | 22 | 13 | 690 | 169 | 0.0176 | 2.41 (1.09 - 5.12) |
GT (22) | 167 | 2 (1.2%) | 133 | 34 | 579 | 148 | 1.0000 | 1.00 (0.63 - 1.54) |
Markers: S47-S48-S49 | ||||||||
GCT (211) | 25 | 25 (100.0%) | 13 | 12 | 699 | 170 | 0.0015 | 3.78 (1.54 - 9.19) |
GCC (212) | 10 | 1 (10.0%) | 9 | 1 | 703 | 181 | 0.6965 | 0.43 (0.01 - 3.15) |
GTC (222) | 23 | 2 (8.7%) | 17 | 6 | 695 | 176 | 0.4411 | 0.39 (0.44 - 3.77) |
Markers: S47-S48-S49-S50 | ||||||||
GCTC (2112) | 13 | 13 (100.0%) | 8 | 5 | 704 | 177 | 0.1546 | 2.48 (0.63 - 8.73) |
GCTT (2111) | 12 | 12 (100.0%) | 5 | 7 | 707 | 175 | 0.0041 | 5.64 (1.52 - 22.82) |
GCCC (2122) | 10 | 1 (10.0%) | 9 | 1 | 703 | 181 | 0.6965 | 0.43 (0.01 - 3.15) |
GTCC (2222) | 3 | 2 (66.7%) | 1 | 2 | 711 | 180 | 0.1071 | 7.87 (0.41 – 465.3) |
Sample Set 2 for cases defined by SE ≤ -10 diopters Marker = rs3819142 (S54), Cluster = 0.C | ||||||||
Markers: S54 | ||||||||
C (2) | 290 | 222 (76.6%) | 193 | 97 | 595 | 441 | 0.0055 | 0.68 (0.51 - 0.90) |
Markers: S49-S54 | ||||||||
TC (12) | 253 | 214 (84.6%) | 166 | 87 | 622 | 451 | 0.0274 | 0.72 (0.54 - 0.97) |
CC (22) | 37 | 8 (21.6%) | 27 | 10 | 761 | 528 | 0.0926 | 0.43 (0.23 - 1.15) |