Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study

Table 2 Summary of logistic regression of SNPs with ESRD

SNP	Gene	Inheritance model	Genotypes	OR (95% CI)^a	p-value^a
rs1801275	IL4R	Overdominant	A/A-G/G	1.00
			A/G	0.66 (0.46-0.95)	0.025
rs301640	STAT4 binding site	Log-additive	A	1.82 (1.17-2.83)	0.0064
rs4586	CCL2	Log-additive	C	0.70 (0.54-0.90)	0.0051
rs7830	NOS3	Log-additive	T	1.31 (1.01-1.71)	0.043

Abbreviations: ESRD, end-stage renal disease; IL4R, interleukin 4 receptor; STAT4 signal transducer and activator of transcription 4; CCL2, chemokine (C-C motif) ligand 2; NOS3 nitric oxide synthase 3; OR, odds ratio; 95%CI, 95% confidence interval; p-value, level of significance.
^aOR and p-value of adjusted model by age and gender.

ISSN: 1471-2350