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Table 3 Association of significant EMID2 variants with nasal polyps in AERD patients (n = 114)

From: Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients

SNP/Haplotype MAF   Co-dominant    Dominant    Recessive   
  Polyp-positive (n = 66) Polyp-negative (n = 48) OR(95%CI) P* P corr ** OR(95%CI) P* P corr ** OR(95%CI) P* P corr **
rs6945102C > T 0.205 0.365 0.43(0.22-0.84) 0.01 NS 0.39(0.17-0.86) 0.02 NS 0.27(0.05-1.51) 0.14 -
rs4729697A > G 0.200 0.365 0.42(0.22-0.83) 0.01 NS 0.38(0.17-0.84) 0.02 NS 0.27(0.05-1.57) 0.15 -
rs10237610C > T 0.554 0.438 1.82(1.01-3.29) 0.05 NS 1.50(0.60-3.73) 0.38 - 3.42(1.22-9.60) 0.02 NS
rs221G > A 0.208 0.396 0.35(0.18-0.70) 0.003 NS 0.35(0.16-0.78) 0.01 NS 0.10(0.01-0.87) 0.04 NS
rs10435333G > A 0.212 0.396 0.36(0.18-0.71) 0.003 NS 0.36(0.16-0.81) 0.01 NS 0.09(0.01-0.85) 0.04 NS
rs9640666G > A 0.326 0.479 0.46(0.25-0.86) 0.02 NS 0.35(0.15-0.84) 0.02 NS 0.43(0.14-1.35) 0.15 -
rs6947185C > A 0.400 0.531 0.52(0.28-0.94) 0.03 NS 0.27(0.10-0.74) 0.01 NS 0.65(0.25-1.69) 0.37 -
rs4729705C > T 0.371 0.521 0.50(0.28-0.88) 0.02 NS 0.25(0.10-0.63) 0.003 NS 0.66(0.25-1.70) 0.38 -
rs10254310G > A 0.432 0.552 0.58(0.34-1.01) 0.06 - 0.39(0.15-0.98) 0.04 NS 0.60(0.25-1.46) 0.26 -
rs6949799T > C 0.546 0.417 1.77(1.02-3.08) 0.04 NS 1.83(0.77-4.34) 0.17 - 2.61(1.00-6.80) 0.05 NS
rs4727491G > A 0.538 0.417 1.74(1.00-3.05) 0.05 NS 1.83(0.77-4.34) 0.17 - 2.48(0.95-6.51) 0.06 -
rs13238748G > C 0.371 0.521 0.50(0.28-0.88) 0.02 NS 0.25(0.10-0.63) 0.003 NS 0.66(0.25-1.70) 0.38 -
rs4727494G > A 0.220 0.385 0.46(0.25-0.86) 0.01 NS 0.37(0.16-0.84) 0.02 NS 0.36(0.10-1.37) 0.14 -
rs13233066G > A 0.227 0.385 0.49(0.27-0.90) 0.02 NS 0.37(0.16-0.84) 0.02 NS 0.45(0.13-1.58) 0.21 -
EMID2_BL1_ht1 0.538 0.417 1.83(1.02-3.26) 0.04 NS 1.38(0.58-3.31) 0.47 - 4.23(1.42-12.57) 0.01 NS
EMID2_BL1_ht2 0.159 0.323 0.37(0.18-0.77) 0.008 NS 0.34(0.15-0.77) 0.01 NS 0.22(0.02-2.18) 0.19 -
EMID2_BL2_ht2 0.220 0.385 0.46(0.25-0.86) 0.01 NS 0.37(0.16-0.84) 0.02 NS 0.36(0.10-1.37) 0.14 -
  1. *P-values at 0.05 level of significance adjusted for initial diagnosed age, sex, smoking status, and atopy. Significant values are shown in bold.
  2. **P-values after multiple testing corrections (Meff = 42.7377).
  3. MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; NS, not significant.