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Figure 1 | BMC Medical Genetics

Figure 1

From: The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Figure 1

Quantitative estimate of FMR1 -mRNA levels in one WT (panel A) and three FXS (panels B-D) cell lines treated for 3 and 8 days with 1, 10, 100 and 1,000 μM AFQ056, respectively. Real-time fluorescent RT-PCR was normalized to a WT untreated cell line. The same cell lines were also treated with [1 μM] 5-azadC to test the efficiency of transcriptional reactivation and also with the drug diluent (mock). The data are expressed as fractions of the value observed in the untreated WT, arbitrarily set at 1.

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BMC Medical Genetics

ISSN: 1471-2350

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