Leukotriene B4 receptor locus gene characterisation and association studies in asthma

BMC Medical Genetics

Table 5 ALOX5AP and LTA4H SNP association analysis with BTS score 1 to 5 in 370 families

SNP	Gene Location	Alleles	MAF	Fam	Z-score	P-value
*ALOX5AP*
SG13S25	5′UTR	G/A	0.109	118	+0.977	0.329
SG13S114	Intron1	T/A	0.323	245	+2.397	0.017
rs3803277	Intron2	C/A	0.445	283	+1.818	0.069
SG13S89	Intron3	G/A	0.042	54	+1.886	0.059
rs4468448	Intron4	C/T	0.242	239	+1.183	0.237
SG13S32	Intron4	C/A	0.474	272	+1.617	0.106
SG13S41	Intron4	A/G	0.067	80	+2.778	0.005
SG13S35	3′UTR	G/A	0.078	97	+1.057	0.291
*LTA4H*
rs1978331	Intron11	T/C	0.417	261	−1.865	0.062
rs17677715	Intron6	T/C	0.193	187	−1.974	0.048
rs2540482	5′UTR	T/C	0.222	209	−2.468	0.014
rs2660845	5′UTR	A/G	0.261	225	−0.856	0.392
rs2540475	5′UTR	C/T	0.215	212	−1.103	0.270

The z score indicates the direction of the association (for continuous traits + indicates the allele confers higher trait values and – indicates the allele confers lower trait values). The z score is a measure of transmission equilibrium i.e. the deviation from the number of times an allele was transmitted to affected offspring and the number of times it should be transmitted under the null hypothesis of no association, no linkage. Number of families in analysis (≥10 families).

ISSN: 1471-2350