Table 2 Meta-analysis of the IL-18 gene polymorphisms and RA risk
Genetic model | Comparisons | Test of association | Test of heterogeneity | Publication bias | ||||
|---|---|---|---|---|---|---|---|---|
OR | 95 % CI | Pvalue | Model | I2 | Pvalue | Pvalue | ||
rs1946518 | ||||||||
Additive | 7 | 0.752 | 0.562-1.006 | 0.055 | R | 77.80% | <0.001 | 0.065 |
Dominant | 7 | 0.730 | 0.479-1.113 | 0.144 | R | 74.40% | 0.001 | 0.067 |
Recessive | 7 | 0.537 | 0.271-1.064 | 0.075 | R | 76.20% | <0.001 | 0.290 |
rs187238 | ||||||||
Additive | 5 | 1.316 | 0.828-2.092 | 0.246 | R | 48.90% | 0.098 | 0.845 |
Dominant | 4 | 1.196 | 0.466-3.073 | 0.710 | F | 45.80% | 0.136 | 0.445 |
Recessive | 5 | 1.347 | 0.963-1.885 | 0.082 | F | 22.40% | 0.272 | 0.657 |