Table 1 Characteristics of studies included in a meta-analysis of the IL-18 polymorphisms and rheumatoid arthritis and systemic lupus erythematosus
Disease | Author(year) | Country | Population | Sample size | Polymorphisms evaluated | Genotyping | HWE in controls |
|---|---|---|---|---|---|---|---|
(cases/controls) | Pvalue | ||||||
RA | Sivalingam SP.2003 [23] | Singapore | Chinese | 309(74/235) | rs1946518 | PCR-SSP | <0.001 |
RA | Sivalingam SP.2003 [23] | Singapore | Chinese | 309(74/235) | rs187238 | PCR-SSP | 0.442 |
RA | Sivalingam SP.2003 [23] | Singapore | Indian | 45(23/22) | rs1946518 | PCR-SSP | 0.079 |
RA | Sivalingam SP.2003 [23] | Singapore | Indian | 45(23/22) | rs187238 | PCR-SSP | 0.548 |
RA | Sivalingam SP.2003 [23] | Singapore | Malay | 25(9/16) | rs1946518 | PCR-SSP | 0.605 |
RA | Sivalingam SP.2003 [23] | Singapore | Malay | 25(9/16) | rs187238 | PCR-SSP | 0.904 |
RA | Huang XZ.2007 [11] | China | Chinese | 287(119/168) | rs1946518 | PCR-SSP | 0.783 |
RA | Huang XZ.2007 [11] | China | Chinese | 288(120/168) | rs187238 | PCR-SSP | 0.728 |
RA | Sugiura T.2011 [25] | Japan | Japanese | 2432(1462/970) | rs1946518 | TaqMan | 0.052 |
RA | Ying B.2011 [14] | China | Chinese | 360(164/196) | rs1946518 | PCR–RFLP | 0.543 |
RA | Shi P.2011 [26] | China | Chinese | 207(107/100) | rs1946518 | PCR-SSP | 0.115 |
RA | Shi P.2011 [26] | China | Chinese | 207(107/100) | rs187238 | PCR-SSP | 0.677 |
SLE | Xu Q.2007 [12] | Singapore | Chinese | 231(113/118) | rs1946518 | PCR–RFLP | 0.050 |
SLE | Xu Q.2007 [12] | Singapore | Chinese | 231(113/118) | rs187238 | PCR-SSP | 0.334 |
SLE | Lin YJ.2007 [13] | China(Taiwan) | Chinese | 301(160/141) | rs1946518 | Probe hybridization | 0.088 |
SLE | Lin YJ.2007 [13] | China(Taiwan) | Chinese | 307(161/146) | rs187238 | Probe hybridization | 0.290 |
SLE | Lan Y.2008 [27] | China | Chinese | 275(115/160) | rs1946518 | PCR–RFLP | 0.606 |
SLE | Lan Y.2008 [27] | China | Chinese | 275(115/160) | rs187238 | PCR–RFLP | 0.727 |
SLE | Chen DY.2009 [28] | China(Taiwan) | Chinese | 339(165/174) | rs1946518 | PCR–RFLP | 0.130 |
SLE | Hirankarn N.2009 [29] | Thailand | Thai | 258(116/142) | rs1946518 | PCR-SSP | 0.061 |
SLE | Hirankarn N.2009 [29] | Thailand | Thai | 258(116/142) | rs187238 | PCR-SSP | 0.868 |
SLE | Ye ZZ.2009 [24] | China | Chinese | 289(165/124) | rs1946518 | PCR-SSP | 0.549 |
SLE | Ye ZZ.2009 [24] | China | Chinese | 289(165/124) | rs187238 | PCR-SSP | 0.030 |