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Table 3 Anthropometric and metabolic characteristics of successfully genotyped non-obese (BMI < 30 kg/m2) glucose-tolerant Danish individuals from the Inter99 study according to rs1209523 FOXA2 genotype

From: The effect of FOXA2rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals

rs1209523 CC CT TT β [95%CI] p add
n (men/women) 3,597(1,663/1,934) 244(121/123) 8(6/2)   
Age (years)¥ 45.1 ± 7.9 44.7 ± 7.2 45.7 ± 7.2   
BMI¥ 24.1 ± 7.9 24.7 ± 2.8 25.8 ± 2.4 0.32 [-0.004; 0.65] 0.05
Plasma glucose (mmol/l)      
Fasting¥ 5.3 ± 0.4 5.2 ± 0.4 5.6 ± 0.3 -0.03 [-0.07; 0.02] 0.3
30-min during an OGTT¥ 8.1 ± 1.5 8.2 ± 1.4 8.9 ± 1.1 0.05 [-0.13; 0.22] 0.6
120-min during an OGTT¥ 5.4 ± 1.1 5.4 ± 1.1 5.3 ± 1.2 -0.01 [-0.15;0.12] 0.8
Incremental AUC¥ 176 ± 102 182 ± 96 185 ± 73 5.64 [-6.64; 17.92] 0.4
Serum insulin (pmol/l)      
Fasting 29 (21-41) 32 (22-44) 42 (30-50) 6.5% [0.02; 13.0] 0.2
30-min during an OGTT 229 (168-321) 244 (186-327) 314 (232-425) 9.2% [2.9; 15.6] 0.01
120-min during an OGTT 131 (83-194) 135 (92-198) 212 (120-240) 10.9% [2.5; 19.4] 0.03
Incremental AUC 16,880 (12,140-23,300) 16,500 (13,240-23,430) 18,360 (14,250-28,120) 9.1% [2.4; 15.9] 0.02
Serum C-peptide (pmol/l)      
Fasting 473 (381-592) 495 (398-604) 602 (564-726) 4.7% [0.6; 8.8] 0.09
30-min during an OGTT 1,820 (1,440-2,280) 1,920 (1,525-2,315) 2,505 (1,685-2,738) 5.2% [1.0; 9.4] 0.05
120-min during an OGTT 1,900 (1,450-2,400) 1,950 (1,548-2,420) 2,485 (1,975-2,968) 5.8% [1.2; 10.4] 0.03
Incremental AUC 144,200 (115,100-177,800) 149,000 (122,000-182,000) 176,500 (150,000-199,400) 5.4% [1.3; 9.5] 0.03
Derived indices      
β-cell function      
Insulinogenic index 24.7 (17.3-35.7) 24.9 (18.5-36.9) 34.3 (19.7-42.4) 8.2% [1.2; 15.1] 0.04
BIGTT-AIR 1,596 (1,311-1,973) 1,665 (1,361-2,060) 1,455 (1,238-2,500) 5.7% [1.4; 10.0] 0.01
HOMA-B 337 (240-399) 367 (263-515) 401 (310-488) 6.7% [0.4; 13.1] 0.04
AUCinsulin/AUCglucose 26.0 (19.6-34.9) 27.0 (20.4-37.9) 29.2 (23.2-40.8) 7.7% [2.0; 13.5] 0.01
Insulin sensitivity      
HOMA-IR 7.0 (4.9-9.8) 7.5 (5.0-10.6) 10.5 (7.8-11.8) 5.9% [-0.8; 12.7] 0.2
BIGTT-Si ¥ 11.0 ± 3.3 10.6 ± 3.5 8.6 ± 3.3 -0.53 [-0.95; 0.10] 0.02
ISIMatsuda 27.4 (19.9-36.9) 26.6 (18.1-35.7) 19.2 (15.0-26.5) -7.2% [-13.5; -1.1] 0.02
β-cell function corrected for insulin sensitivity      
Disposition index 3.6 (2.4-5.3) 3.9 (2.4-5.6) 3.9 (3.0-4.2) 2.5% [-5.4; 10.5] 0.5
  1. Data are unadjusted means ± SD¥ or medians (interquartile range). Values of serum insulin, serum c-peptide, and insulin-derived indices were logarithmically transformed prior to statistical analyses, and their effect sizes are presented as the increase/decrease in percent. Effect sizes (β) and p-values shown are for an additive genetic model and are adjusted for age and sex. CI, confidence interval; add, additive; AUC, area under the curve.