Association of CD14 -260 (-159) C>Tand asthma: a systematic review and meta-analysis

BMC Medical Genetics

Table 1 Characteristics and genotype distributions of reviewed studies on CD14 -260 (-159) C>T and asthma.

Study	Country	Study design	Outcome	Cases				Controls
					Genotypes				Genotypes
				N	CC	CT	TT	N	CC	CT	TT	HWE p
European
Bjornvold [24]^a	Norway	CC	AA	103	39	49	15	479	161	233	85	-
de Faria [27]	Brazil	CC	AA	88	27	41	20	202	63	131	8	< 0.01
Hakonarson [28]^a	Iceland	CC	AA	94	31	46	17	94	29	46	19	-
Heinzmann [29]	Germany	CC	MA	182	51	89	42	261	79	124	58	0.48
Kedda [11]^{b, c}	Australia	CC	AA, NAA	568	148	284	136	443	124	226	93	0.59
Koppelman [30]	Netherlands	CC	MA	159	51	76	32	158	31	85	42	0.31
Kowal [31]	Poland	CC	AA	372	141	152	79	160	42	73	45	0.27
Lis [32]	Poland	CC	AA	50	20	24	6	73	28	34	11	0.90
Murk [4]	USA	CC	AA	97	31	55	11	473	137	236	100	0.93
Sengler [33]	Germany	NCC	MA	84	23	43	18	119	26	72	21	0.02
Smit [34]	Denmark	NCC	MA	100	34	47	19	88	26	47	15	0.42
Smit [35]	France	CC	MA	223	49	107	67	554	145	276	133	0.94
Woo [36]^b	USA	CC	AA, NAA	175	46	94	35	61	20	35	6	0.10
Subtotal				2295	691	1107	497	3165	911	1618	636
East Asian
Chan [20]^d	Hong Kong	CC	MA	269	55	134	80	141	26	77	38	0.23
Chen [25]	China	CC	MA	150	63	62	25	150	40	68	42	0.25
Cui [26]	China	CC	AA	143	27	67	49	72	10	42	20	0.11
Hong [37]^b	South Korea	CC	AA, NAA	626	113	284	229	153	22	71	60	0.89
Kuo Chou [38]	Taiwan	CC	MA	116	17	64	35	232	45	118	69	0.67
Park [39]	South Korea	CC	MA	85	16	39	30	550	90	267	193	0.88
Wang [23]	Taiwan	CC	MA	447	57	230	160	509	96	236	177	0.27
Wu [40]	China	CC	MA	252	54	117	81	227	31	121	75	0.10
Subtotal				2088	402	997	689	2034	360	1000	674
Indian
Sharma [41]	India	CC	AA	187	43	92	52	227	30	112	85	0.47
North African
Lachheb [42]^b	Tunisia	CC	AA, NAA	210	46	90	74	224	36	72	116	< 0.01
*Total*				*4780*	*1182*	*2286*	*1312*	*5650*	*1337*	*2802*	*1511*

The number of successfully genotyped cases and controls may be less than the total number of cases and controls in the study (i.e. SNP call rate < 100%). Genotype frequencies presented as reported, otherwise calculated from reported genotype percent frequencies. Abbreviations: AA, atopic asthma; CC, case-control; HWE, Hardy-Weinberg equilibrium; MA, mixed asthma; N, genotyped sample size; NA, non-asthma; NAA, non-atopic asthma; NANA, non-atopic non-asthma; NCC, nested case-control.
^a Genotype frequencies estimated based on allele frequencies assuming HWE among cases and controls.
^b Genotype distribution for AA cases shown (genotype distribution for NAA cases not shown).
^c Genotype distribution for NA controls shown (genotype distribution for NANA controls not shown).
^d Genotype frequency information from this data set for atopic asthma cases and corresponding controls (not shown) abstracted from Leung et al. [21].

ISSN: 1471-2350