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Table 2 SNPs genotyped in discovery cases and controls with p <0.1

From: Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype

Gene

SNP

Minor allele and strand

Logistic regression adjusted p value

Genotypic association OR (95% CI) Heterozygous (Het) Homozygous minor (HM)

Genotype Frequencies minor/het/major Cases (Ca) Pop. Controls (PC)

LOXL1

rs12442211

G/-

0.066

Het: 0.60 (0.37 - 0.95)

Ca: 27/54/47

    

HM: 0.60 (0.34 - 1.04)

PC: 100/198/101

LOXL1

rs2304719

T/-

0.063

Het: 0.61 (0.39 - 0.96)

Ca: 17/39/69

    

HM: 1.12 (0.59 - 2.14)

PC: 40/171/189

LOXL1

rs4461027

C/-

0.058

Het: 0.59 (0.38 - 0.91)

Ca: 23/46/62

    

HM: 0.72 (0.41 - 1.26)

PC: 71/186/142

LOXL1

rs4886782

A/-

0.031

Het: 0.56 (0.36 - 0.86)

Ca: 18/43/69

    

HM: 0.86 (0.46 - 1.58)

PC: 51/186/161

LOXL2

rs1002791

C/+

0.039

Het: 0.58 (0.38 - 0.90)

Ca: 6/39/82

    

HM: 0.58 (0.23 - 1.47)

PC: 26/166/208

LOXL2

rs17760913

T/-

0.055

Het: 0.66 (0.42 - 1.04)

Ca: 12/34/86

    

HM: 1.62 (0.76 - 3.46)

PC: 21/142/227

LOXL2

rs17760943

A/-

0.072

Het: 0.77 (0.49 - 1.19)

Ca: 16/39/76

    

HM: 1.75 (0.89 - 3.44)

PC: 28/150/222

LOXL2

rs2294125

G/+

0.10

Het: 0.67 (0.41 - 1.08)

Ca: 36/52/41

    

HM: 1.09 (0.64 - 1.85)

PC: 88/201/107

LOXL2

rs3808522

G/-

0.0046

Het: 0.48 (0.28 - 0.82)

Ca: 37/30/46

    

HM: 1.15 (0.68 - 1.94)

PC: 80/150/111

LOXL2

rs3808536

C/+

0.0059

Het: 0.69 (0.42 - 1.11)

Ca: 40/47/40

    

HM: 1.57 (0.92 - 2.68)

PC: 73/200/119

LOXL2

rs6985160

T/-

0.035

Het: 0.59 (0.38 - 0.90)

Ca: 14/47/68

    

HM: 0.59 (0.30 - 1.13)

PC: 55/185/155

LOXL2

rs6999447

T/-

0.027

Het: 0.86 (0.55 - 1.35)

Ca: 29/50/53

    

HM: 1.85 (1.06 - 3.24)

PC: 48/182/170

LOXL4

rs11189510

A/+

0.00045

Het: 2.30 (1.45 - 3.66)

Ca: 5/39/87

    

HM: 3.84 (1.09-13.58)

PC: 6/68/325

LOXL4

rs11189513

G/-

0.036

Het: 1.23 (0.81 - 1.87)

Ca: 9/60/60

    

HM: 0.45 (0.21 - 0.97)

PC: 63/151/183

LOXL4

rs11599085

C/+

0.067

Het: 1.69 (1.09 - 2.64)

Ca: 17/76/39

    

HM: 1.39 (0.72 - 2.66)

PC: 53/185/164

LOXL4

rs751160

G/-

0.093

Het: 0.69 (0.44 - 1.07)

Ca: 22/48/59

    

HM: 1.26 (0.69 - 2.30)

PC: 47/190/157

  1. The SNPs genotyped in the discovery phase (138 cases and 411 controls) with overall p <0.1 are represented. The minor allele and strand are represented to allow for comparisons between studies. The p-value displayed indicates the significance of the overall model and is adjusted for gender. The odds ratios use the homozygous major allele genotype as the reference genotype and genotype counts are presented for each group.
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BMC Medical Genetics

ISSN: 1471-2350

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