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Table 2 SNPs genotyped in discovery cases and controls with p <0.1

From: Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype

Gene SNP Minor allele and strand Logistic regression adjusted p value Genotypic association OR (95% CI) Heterozygous (Het) Homozygous minor (HM) Genotype Frequencies minor/het/major Cases (Ca) Pop. Controls (PC)
LOXL1 rs12442211 G/- 0.066 Het: 0.60 (0.37 - 0.95) Ca: 27/54/47
     HM: 0.60 (0.34 - 1.04) PC: 100/198/101
LOXL1 rs2304719 T/- 0.063 Het: 0.61 (0.39 - 0.96) Ca: 17/39/69
     HM: 1.12 (0.59 - 2.14) PC: 40/171/189
LOXL1 rs4461027 C/- 0.058 Het: 0.59 (0.38 - 0.91) Ca: 23/46/62
     HM: 0.72 (0.41 - 1.26) PC: 71/186/142
LOXL1 rs4886782 A/- 0.031 Het: 0.56 (0.36 - 0.86) Ca: 18/43/69
     HM: 0.86 (0.46 - 1.58) PC: 51/186/161
LOXL2 rs1002791 C/+ 0.039 Het: 0.58 (0.38 - 0.90) Ca: 6/39/82
     HM: 0.58 (0.23 - 1.47) PC: 26/166/208
LOXL2 rs17760913 T/- 0.055 Het: 0.66 (0.42 - 1.04) Ca: 12/34/86
     HM: 1.62 (0.76 - 3.46) PC: 21/142/227
LOXL2 rs17760943 A/- 0.072 Het: 0.77 (0.49 - 1.19) Ca: 16/39/76
     HM: 1.75 (0.89 - 3.44) PC: 28/150/222
LOXL2 rs2294125 G/+ 0.10 Het: 0.67 (0.41 - 1.08) Ca: 36/52/41
     HM: 1.09 (0.64 - 1.85) PC: 88/201/107
LOXL2 rs3808522 G/- 0.0046 Het: 0.48 (0.28 - 0.82) Ca: 37/30/46
     HM: 1.15 (0.68 - 1.94) PC: 80/150/111
LOXL2 rs3808536 C/+ 0.0059 Het: 0.69 (0.42 - 1.11) Ca: 40/47/40
     HM: 1.57 (0.92 - 2.68) PC: 73/200/119
LOXL2 rs6985160 T/- 0.035 Het: 0.59 (0.38 - 0.90) Ca: 14/47/68
     HM: 0.59 (0.30 - 1.13) PC: 55/185/155
LOXL2 rs6999447 T/- 0.027 Het: 0.86 (0.55 - 1.35) Ca: 29/50/53
     HM: 1.85 (1.06 - 3.24) PC: 48/182/170
LOXL4 rs11189510 A/+ 0.00045 Het: 2.30 (1.45 - 3.66) Ca: 5/39/87
     HM: 3.84 (1.09-13.58) PC: 6/68/325
LOXL4 rs11189513 G/- 0.036 Het: 1.23 (0.81 - 1.87) Ca: 9/60/60
     HM: 0.45 (0.21 - 0.97) PC: 63/151/183
LOXL4 rs11599085 C/+ 0.067 Het: 1.69 (1.09 - 2.64) Ca: 17/76/39
     HM: 1.39 (0.72 - 2.66) PC: 53/185/164
LOXL4 rs751160 G/- 0.093 Het: 0.69 (0.44 - 1.07) Ca: 22/48/59
     HM: 1.26 (0.69 - 2.30) PC: 47/190/157
  1. The SNPs genotyped in the discovery phase (138 cases and 411 controls) with overall p <0.1 are represented. The minor allele and strand are represented to allow for comparisons between studies. The p-value displayed indicates the significance of the overall model and is adjusted for gender. The odds ratios use the homozygous major allele genotype as the reference genotype and genotype counts are presented for each group.