|
Gene
|
SNP
|
Minor allele and strand
|
Logistic regression adjusted p value
|
Genotypic association OR (95% CI) Heterozygous (Het) Homozygous minor (HM)
|
Genotype Frequencies minor/het/major Cases (Ca) Pop. Controls (PC)
|
|---|
|
LOXL1
|
rs12442211
|
G/-
|
0.066
|
Het: 0.60 (0.37 - 0.95)
|
Ca: 27/54/47
|
| | | | |
HM: 0.60 (0.34 - 1.04)
|
PC: 100/198/101
|
|
LOXL1
|
rs2304719
|
T/-
|
0.063
|
Het: 0.61 (0.39 - 0.96)
|
Ca: 17/39/69
|
| | | | |
HM: 1.12 (0.59 - 2.14)
|
PC: 40/171/189
|
|
LOXL1
|
rs4461027
|
C/-
|
0.058
|
Het: 0.59 (0.38 - 0.91)
|
Ca: 23/46/62
|
| | | | |
HM: 0.72 (0.41 - 1.26)
|
PC: 71/186/142
|
|
LOXL1
|
rs4886782
|
A/-
|
0.031
|
Het: 0.56 (0.36 - 0.86)
|
Ca: 18/43/69
|
| | | | |
HM: 0.86 (0.46 - 1.58)
|
PC: 51/186/161
|
|
LOXL2
|
rs1002791
|
C/+
|
0.039
|
Het: 0.58 (0.38 - 0.90)
|
Ca: 6/39/82
|
| | | | |
HM: 0.58 (0.23 - 1.47)
|
PC: 26/166/208
|
|
LOXL2
|
rs17760913
|
T/-
|
0.055
|
Het: 0.66 (0.42 - 1.04)
|
Ca: 12/34/86
|
| | | | |
HM: 1.62 (0.76 - 3.46)
|
PC: 21/142/227
|
|
LOXL2
|
rs17760943
|
A/-
|
0.072
|
Het: 0.77 (0.49 - 1.19)
|
Ca: 16/39/76
|
| | | | |
HM: 1.75 (0.89 - 3.44)
|
PC: 28/150/222
|
|
LOXL2
|
rs2294125
|
G/+
|
0.10
|
Het: 0.67 (0.41 - 1.08)
|
Ca: 36/52/41
|
| | | | |
HM: 1.09 (0.64 - 1.85)
|
PC: 88/201/107
|
|
LOXL2
|
rs3808522
|
G/-
|
0.0046
|
Het: 0.48 (0.28 - 0.82)
|
Ca: 37/30/46
|
| | | | |
HM: 1.15 (0.68 - 1.94)
|
PC: 80/150/111
|
|
LOXL2
|
rs3808536
|
C/+
|
0.0059
|
Het: 0.69 (0.42 - 1.11)
|
Ca: 40/47/40
|
| | | | |
HM: 1.57 (0.92 - 2.68)
|
PC: 73/200/119
|
|
LOXL2
|
rs6985160
|
T/-
|
0.035
|
Het: 0.59 (0.38 - 0.90)
|
Ca: 14/47/68
|
| | | | |
HM: 0.59 (0.30 - 1.13)
|
PC: 55/185/155
|
|
LOXL2
|
rs6999447
|
T/-
|
0.027
|
Het: 0.86 (0.55 - 1.35)
|
Ca: 29/50/53
|
| | | | |
HM: 1.85 (1.06 - 3.24)
|
PC: 48/182/170
|
|
LOXL4
|
rs11189510
|
A/+
|
0.00045
|
Het: 2.30 (1.45 - 3.66)
|
Ca: 5/39/87
|
| | | | |
HM: 3.84 (1.09-13.58)
|
PC: 6/68/325
|
|
LOXL4
|
rs11189513
|
G/-
|
0.036
|
Het: 1.23 (0.81 - 1.87)
|
Ca: 9/60/60
|
| | | | |
HM: 0.45 (0.21 - 0.97)
|
PC: 63/151/183
|
|
LOXL4
|
rs11599085
|
C/+
|
0.067
|
Het: 1.69 (1.09 - 2.64)
|
Ca: 17/76/39
|
| | | | |
HM: 1.39 (0.72 - 2.66)
|
PC: 53/185/164
|
|
LOXL4
|
rs751160
|
G/-
|
0.093
|
Het: 0.69 (0.44 - 1.07)
|
Ca: 22/48/59
|
| | | | |
HM: 1.26 (0.69 - 2.30)
|
PC: 47/190/157
|
- The SNPs genotyped in the discovery phase (138 cases and 411 controls) with overall p <0.1 are represented. The minor allele and strand are represented to allow for comparisons between studies. The p-value displayed indicates the significance of the overall model and is adjusted for gender. The odds ratios use the homozygous major allele genotype as the reference genotype and genotype counts are presented for each group.
