Skip to main content

Advertisement

Table 5 Multiple regression analyses of MTNR1B polymorphisms with diabetes-related phenotypes among all subjects

From: Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus

Phenotype Loci C/C C/R R/R Pacor. Pbcor. Pccor.
BMI rs1387153 548(22.38 ± 3.65) 888(22.37 ± 3.65) 445(22.24 ± 3.56) 1 1 1
  rs10830963 511(22.34 ± 3.60) 904(22.33 ± 3.58) 459(22.37 ± 3.75) 1 1 1
AUC_G* rs1387153 454(419.91 ± 81.85) 743(431.31 ± 79.96) 386(439.26 ± 74.28) 0.0007 0.004 0.03
  rs10830963 419(421.23 ± 85.41) 763(429.09 ± 78.39) 403(439.14 ± 74.58) 0.002 0.04 0.03
HOMA_B* rs1387153 541(252.38 ± 190.86) 882(239.90 ± 143.11) 437(222.90 ± 125.81) 0.01 0.29 0.07
  rs10830963 505(251.36 ± 191.00) 897(240.78 ± 143.84) 451(223.74 ± 128.37) 0.03 0.72 0.04
HOMA_IR* rs1387153 543(2.53 ± 1.63) 882(2.59 ± 1.35) 440(2.64 ± 1.62) 1 1 1
  rs10830963 507(2.53 ± 1.47) 897(2.57 ± 1.43) 454(2.69 ± 1.65) 1 1 1
FPI* rs1387153 543(11.98 ± 6.21) 882(12.15 ± 5.34) 440(12.26 ± 6.56) 1 1 1
  rs10830963 507(11.91 ± 5.59) 897(12.07 ± 5.61) 454(12.44 ± 6.64) 1 1 1
FPG rs1387153 454(84.30 ± 12.71) 743(85.55 ± 12.01) 386(86.58 ± 12.94) 0.01 0.07 0.22
  rs10830963 419(84.63 ± 13.24) 763(85.13 ± 11.62) 403(86.71 ± 12.99) 0.04 0.72 0.07
  1. P value was calculated from multiple linear regression analyses controlling for age, BMI, and number of parities as covariates except BMI phenotypes, which was adjusted for age and number of parities as covariates only. Pa, Pb, and Pc designate P values for co-dominant, dominant, and recessive models, respectively. P values were corrected for multiple testing by multiplying the number of tests (36 tests, 2 SNPs × 3 models × 6 phenotypes) (Bonferroni correction). C/C, C/R, and R/R indicate major homozygote, heterozygote, and minor homozygote, respectively. * P values for AUC_G, HOMA_B, HOMA_IR, and FPI were calculated after normalizing their data by applying logarithms (Data shown are raw values). FPI, fasting plasma insulin; FPG, fasting plasma glucose