Table 1 Allelic and genotypic frequencies of -1082G > A and -592C > A IL-10 gene promoter variants
Males | Females | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control (n = 201) | Schizophrenia (n = 153) | OR (95%CI) | P | Control (n = 234) | Schizophrenia (n = 88) | OR (95% CI) | P | |||||
Age (years) | 37 ± 18 | 45 ± 13 | 0.000* | 39 ± 18 | 46 ± 13 | 0.002* | ||||||
-1082G > A Allelic frequencies | n | % | n | % | p | n | % | n | % | |||
G | 164 | 40.8% | 111 | 36.3% | 1.21 (0.88-1.66) | 0.252 | 198 | 42.3% | 57 | 32.4% | 1.53 (1.04-2.25) | 0.027* |
A | 238 | 59.2% | 195 | 63.7% | 270 | 57.7% | 119 | 67.6% | ||||
Genotypic frequencies | ||||||||||||
G/G | 38 | 18.9% | 23 | 15.0% | 0.502 | 33 | 14.1% | 11 | 12.5% | 0.008* | ||
G/A | 88 | 43.8% | 65 | 42.5% | 132 | 56.4% | 35 | 39.8% | ||||
A/A | 75 | 37.3% | 65 | 42.5% | 69 | 29.5% | 42 | 47.7% | ||||
-592 C > A Allelic frequencies | n | % | n | % | OR (95%CI) | p | n | % | n | % | OR (95% CI) | p |
C | 274 | 75.7% | 227 | 72.8% | 1.11 (0.77-1.60) | 0.618 | 298 | 74.5% | 123 | 69.1% | 0.76 (0.51-1.15) | 0.213 |
A | 88 | 24.3% | 79 | 25.3% | 102 | 25.5% | 53 | 29.8% | ||||
Genotypic frequencies | ||||||||||||
C/C | 110 | 60.8% | 84 | 53.8% | 0.134 | 106 | 53.0% | 47 | 52.8% | 0.004* | ||
C/A | 54 | 29.8% | 59 | 37.8% | 86 | 43.0% | 29 | 32.6% | ||||
A/A | 17 | 9.4% | 10 | 6.4% | 8 | 4.0% | 12 | 13.5% | ||||