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Table 3 Variation in sex-steroid hormone synthesizing enzymes and receptor in relation to colorectal cancer risk in the Women's Health Initiative Observational Cohort

From: Estrogen and progesterone-related gene variants and colorectal cancer risk in women

Gene/Variant N total (case/control) MAF %1(case/control) OR (95% CI) 2 P trend 3 corrected P trend 4
CYP17A1      
rs10883782 410/834 15/18 0.78 (0.61-0.98) 0.03 0.22
rs17724534 406/829 15/12 1.39 (1.08-1.78) 0.009 0.07
CYP19A1      
rs1902584 410/811 6/5 1.45 (1.07-1.98) 0.02 0.36
ESR1      
rs9340837 424/866 12/9 1.37 (1.05-1.79) 0.02 0.73
CYP17A1      
rs10883782 47/102 17/13 1.40 (0.72-2.73) 0.32 0.92
rs17724534 50/103 1/4 0.22 (0.03-1.74) 0.12 0.72
CYP19A1      
rs1902584 52/108 6/7 0.79 (0.28-2.25) 0.67 0.99
ESR1      
rs9340837 52/107 46/46 1.02 (0.64-1.62) 0.95 0.99
  1. 1. MAF = minor allele frequency.
  2. 2.For each variant, odds ratios are per copy of the risk allele.
  3. 3. Pointwise 10,000 permutation tests.
  4. 4. Familywise 10,000 permutation tests.