Figure 1

The Folate and methionine cycles. Abreviations: 10f-THF: 10-formyltetrahydrofolate; 5,10-CH2-THF: 5,10-methylenetetrahydrofolate; 5,10-CH-THF: 5,10-methenyltetrahydrofolate; 5mTHF: 5-methyltetrahydrofolate; AICART: Aminoimidazolecarboxamide ribotide transformylase; ATIC: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/imp cyclohydrolase; BHMT: Betaine-homocysteine methyltransferase; CBS: Cystathionine beta-synthase; DHF: Dihydrofolate reductase; DNMT: S-adenosylmethionine-dependent methyltransferases; DNMT, DNA methyltransferase; FTD: 10-formyltetrahydrofolate dehydrogenase; FTS: 10-formyltetrahydrofolate synthase; GNMT: glycine N-methyltransferase; GST: Glutathione S-transferase; MAT: methionine adenosyltransferase; MTCH: 5,10-methylenetetrahydrofolate cyclohydrolase; MTD: Methylenetetrahydrofolate dehydrogenase; MTHFR: 5,10-methylenetetrahydrofolate reductase; MTR: 5-methyltetrahydrofolate-homocysteine S-methyltransferase; MTRR: Methionine synthase reductase; NE: nonenzymatic interconversion of THF; PGT: phosphoribosyl glycinamidetransformylase; SAH: S-adenosylhomocysteine; SAHH: S-adenosyl homocysteine hydrolase; SAM: S-adenosylmethionine; SHMT: Serine hydroxymethyltransferase; TCN2: Transcobalamin II; THF: tetrahydrofolate; TS: thymidylate synthase; TYMS: Thymidylate synthetase.