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Table 1 Allelic frequencies and genotype distribution of the MAOA uVNTR polymorphism in the four groups of participants, namely, community controls, subjects from the community who had attempted suicide, and patients with major depressive disorder who had or had not attempted suicide

From: Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder

   

Genotype distribution, N (%)

Group

Age

N (%)

R2/R2

R2/R3

R2/R4

R3/R3

R3/R4

R3/R5

R4/R4

R4/R5

Comm-contl

45.36 ± 13.91

420

        

Male

 

182(43.33%)

        

Female

 

238(56.67%)

   

88(36.97%)

108(45.38%)

1(0.42%)

38(15.97%)

3(1.26%)

MDD

45.17 ± 15.25

379

        

Male

 

146(38.52%)

        

Female

 

233(61.48%)

1(0.43%)

1(0.43%)

1(0.43%)

81(34.76%)

109(46.78%)

 

40(17.17%)

 

Comm-suic

45.48 ± 20.53

74

        

Male

 

36(48.65%)

        

Female

 

38(51.35%)

   

11(28.95%)

22(57.89%)

 

5(15.16%)

 

MDD-suic

39.73 ± 14.71

104

        

Male

 

46(44.23%)

        

Female

 

58(55.77%)

   

24(41.38%)

26(44.83%)

 

8(13.79%)

 
 

Allelic frequency, N (%)

Comm-contl

MDD

Comm-suic

Group

R2

R3

R4

R5

χ2

P

χ2

P

χ2

P

Comm-contl

 

396(60.18%)

257(39.06%)

5(0.76%)

      

Male

 

111(60.98%)

70(38.46%)

1(0.54%)

      

Female

 

285(59.87%)

187(39.29%)

4(0.84%)

      

MDD

6(0.98%)

344(56.21%)

262(42.81%)

 

1.950

0.163

    

Male

2(1.37%)

72(48.32%)

72(48.32%)

 

4.182

0.041*

    

Female

4(0.86%)

272(58.37%)

190(40.77%)

 

0.220

0.639

    

Comm-suic

2(1.79%)

63(56.25%)

47(41.96%)

 

0.446

0.504

0.010

0.921

  

Male

2(5.55%)

19(52.78%)

15(41.67%)

 

0.355

0.551

0.381

0.537

  

Female

 

44(57.89%)

32(42.11%)

 

0.169

0.681

0.026

0.872

  

MDD-suic

2(1.23%)

96(59.26%)

64(39.51%)

 

0.022

0.881

0.542

0.462

0.200

0.655

Male

2(4.34%)

22(47.83%)

22(47.83%)

 

1.879

0.170

0.000

1.000

0.266

0.606

Female

 

74(63.79%)

42(36.21%)

 

0.456

0.500

0.934

0.334

0.674

0.412

  1. comm-contl: community controls; MDD: subjects with major depressive disorder; Comm-suic: community subjects who had attempted suicide; MDD-suic: subjects with major depressive disorder who had attempted suicide; N: the number of genotyped subjects; χ2: the chi-squared value from Pearson's uncorrected method; asterisk indicates statistical significance. The p-value was obtained by comparing the frequencies of R3 and R4 in each pair of groups; the frequencies of R2 and R5 were ignored because they were low in our population. Overall, the female-to-male ratio was 1.385 (568/410).
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BMC Medical Genetics

ISSN: 1471-2350

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