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Table 2 Overall distribution of PRNP regulatory region rare alleles and risk of sporadic CJD

From: A polymorphism in the regulatory region of PRNPis associated with increased risk of sporadic Creutzfeldt-Jakob disease

PRNPSNP

Cases (%)

Controls (%)

OR (95% CI)

P- value

OR (95% CI) *

P- value*

-101G carriers

28 (22.8)

25(20.3)

0.9 (0.5-1.6)

0.64

0.98 (0.52-1.83)

0.95

-101G non carriers

95 (77.2)

98 (79.7)

    

310C carriers

17(13.0)

18 (9.3)

1.5 (0.7-2.9)

0.30

2.4 (1.1-5.4)

0.03

310C non carriers

114 (87.0)

176 (90.7)

    

385C carriers

5 (4.3)

7 (5.4)

1.3 (0.4-4.1)

0.70

0.69 (0.21-2.29)

0.54

385C non carriers

111 (95.7)

123 (94.6)

    
  1. * Adjusted by PRNP M129V polymorphism
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BMC Medical Genetics

ISSN: 1471-2350

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