Figure 1

Acute insulin response (AIR) and acute C-peptide response (ACPR) stratified according to GCKR rs780094 or rs3817588 genotypes by quartile of diabetic duration. * p < 0.05 compared with homozygote of major allele (AA) ** p < 0.01 compared with homozygote of major allele (AA) # p for trend < 0.05 All p values were not significant after Bonferroni correction (p < 0.0016 (0.05/32) was used as Bonferroni corrected statistically significant level in association analysis between the individual SNP and AIR or ACPR) The figures below the genotypes indicate the number of diabetic cases for each genotype group.