CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey

BMC Medical Genetics

Table 4 Adjusted and weighted association between CRP polymorphism rs2808630 and rs3093058 and CKD in African Americans Participants.

Models	Genotype	OR	95% CI	¥ p-value
rs2808630
Fully adjusted model	AA	ref**
	AG	2.94	1.61, 5.38	0.001*
	GG	2.22	0.68, 7.23	0.2
Fully adjusted model plus Log transformed CRP	AA	ref**
	AG	3.09	1.65, 5.80	0.001*
	GG	2.41	0.79, 7.39	0.1
*rs3093058*
Fully adjusted model	AA	ref**
	AT	0.44	0.49,1.44	0.5
	TT	0.15	0.02, 1.36	0.09
Fully adjusted model plus Log transformed CRP	AA	ref**
	AT	0.8	0.45, 1.41	0.4
	TT	0.15	0.02,1.39	0.09

¥ Unadjusted for multiple comparisons
*Statistical significance with Bonferroni correction (α/n = 0.05/29) p-value ≤ 0.002
Number of participants by rs2808630 genotype: AA = 1131; AG 419, and GG = 34
**ref. reference group homozygous for the major allele.
Fully adjusted model: adjusted for age, sex, diabetes, hypertension, cardiovascular disease, BMI, smoking and LDL cholesterol

ISSN: 1471-2350