CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey

BMC Medical Genetics

Table 3 Unadjusted and weighed association of CRP gene polymorphism and CKD, additive genetic model

Presence of CKD (logistic regression) for each SNP
	No			No			No
		Non-Hispanic Whites	¥ p value		Non-Hispanic Blacks	¥ p value		Mexican American	¥ p value
*rs2808630*
AA	1137	ref		1131	ref		1019	Ref
AG	907	1.09 (0.78-1.52)	0.6	419	1.68 (1.34 - 2.12)	0.0001*	523	1.04(0.58-1.88)	0.9
GG	176	0.90 (0.52-1.57)	0.7	34	1.08 (0.43 - 2.71)	0.9	68	1.17(0.57-2.40)	0.7
*rs1205*
GG	935	ref		994	ref		664	Ref
AG	1044	0.88 (0.61-1.28)	0.5	483	1.60 (0.66-3.88)	0.3	758	1.22 (0.76-1.97)	0.4
AA	247	1.07 (0.77-1.48)	0.7	88	1.82 (0.82-4.06)	0.1	199	1.20(0.77-1.89)	0.4
*rs1417938*
AA	1110	ref		1245	ref		701	Ref
AT	969	1.07 (0.76-1.50)	0.7	334	1.08(0.080-1.44)	0.6	746	1.21 (0.92-1.58)	0.2
TT	196	1.08 (0.61-1.93)	0.8	23	0.43(0.09-1.99)	0.3	179	1.10 (0.48-2.50)	0.8
*rs1800947*
GG	2019	ref		1508	ref		1519	Ref
CG	**	1.21 (0.56 - 2.66)	0.6	20	0.55 (0.13-2.26)	0.4	61	0.52 (0.20-1.38)	0.2
*rs3093058*
AA	2255	ref		1127	ref		1608	Ref
AT	11	3.69 (0.74-18.44)	0.09	427	0.76 (0.60-0.96)	0.02	**	1.36 (0.59-3.15)	0.5
TT	-	_		42	0.38 (0.13-1.07)	0.07	**	_
*rs3093066*
CC	2108	ref		905	ref		1577	Ref
CA	24	2.20 (0.65-7.47)	0.2	548	1.11 (0.56-2.21)	0.8	**	0.22 (0.05-0.97)	0.03
AA	-	_		82	0.92 (0.54-1.55)	0.7	**	_

¥ Unadjusted for multiple comparisons
*Statistical significance with Bonferroni correction (α/n = 0.05/29) p-value ≤ 0.002

ISSN: 1471-2350