|  | Dementia N(%) 273 | No dementia N(%) 2247 | Whole sample N(%) 2520 | Crude PR (95%CI) | Adjusted1PR (95%CI) |
---|---|---|---|---|---|---|
APOE genotype | e2/e3 | 24 (8.8%) | 255 (11.4%) | 279 (11.1%) | 0.97 (0.64-1.46) | 0.96 (0.64-1.44) |
 | e2/e4 | 2 (0.7%) | 15 (0.7%) | 17 (0.7%) | 1.33 (0.36-4.91) | 1.42 (0.37-5.45) |
 | e3/e3 | 162 (59.3%) | 1663 (74.0%) | 1825 (72.4%) | 1.00 (ref.) | 1.00 (ref.) |
 | e3/e4 | 77 (28.2%) | 285 (12.7%) | 362 (14.4%) | 2.40 (1.88-3.06) | 2.59 (2.04-3.28) |
 | e4/e4 | 8 (2.9%) | 29 (1.3%) | 37 (1.5%) | 2.44 (1.30-4.57) | 2.88 (1.58-5.27) |
 | p-value (Test for heterogeneity) |  |  |  | X2 = 54.6, 4 df p < 0.001 | X2 = 46.6, 4 df p < 0.001 |
Number of APOE e4 alleles | 0 | 186 (68.1%) | 1918 (85.4%) | 2104 (83.5%) | 1.00 (ref.) | 1.00 (ref.) |
 | 1 | 79 (28.9%) | 300 (13.4%) | 379 (15.0%) | 2.36 (1.86-2.99) | 2.55 (2.02-3.21) |
 | 2 | 8 (2.9%) | 29 (1.3%) | 37 (1.5%) | 2.45 (1.31-4.58) | 2.90 (1.59-5.29) |
 | p-value (Test for trend) |  |  |  | X2 = 55.5, 1 df p < 0.001 | X2 = 41.8, 1 df p < 0.001 |
Any APOE e4 allele | 1 or 2 alleles | 87 (31.9%) | 329 (14.6%) | 416 (16.5%) | 2.37 (1.88-2.98) | 2.58 (2.06-3.22) |
 | p-value |  |  |  | X2 = 53.0, 1 df p < 0.001 | X2 = 45.6, 1 df p < 0.001 |
APOE allele frequency | e2 | 0.048 | 0.060 | 0.059 | Â | Â |
 | e3 | 0.778 | 0.860 | 0.851 |  |  |
 | e4 | 0.174 | 0.080 | 0.090 |  |  |
 | p-value (Test for trend) |  |  | X2 = 61.7, 1 df, P < 0.001 |  |  |