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Table 2 BMS, QUS and sex hormone biochemistry parameters in relation to the distribution of the rs700519 genotype in CAIFOS study (n = 1022)

From: A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture

Variable

Wild type

Variants

P value

Number

997

25

 

Age (years)

74.95 ± 2.60

74.91 ± 2.76

0.83

Weight (Kg)

68.32 ± 11.79

72.19 ± 15.85

0.11

Height (cm)

158.96 ± 5.86

159.35 ± 4.67

0.74

BMI (kg/m 2 )

27.03 ± 4.39

28.53 ± 6.81

0.10

Total fractures (yes/no)

198 (19.9%)

7 (28.0%)

0.27

Hip fractures (yes/no)

28 (2.8%)

1 (4.0%)

0.76

Vertebral fractures n (yes/no)

69 (6.9%)

2 (8.0%)

0.83

Total hip BMD (mg/cm 2 )

0.81 ± 0.12

0.84 ± 0.14

0.48

Femoral neck BMD (mg/cm 2 )

0.69 ± 0.10

0.70 ± 0.12

0.54

Average BUA (dB/MHz)

100.45 ± 7.61

99.46 ± 8.90

0.21

Average SOS (m/s)

1512.62 ± 24.66

1512.83 ± 33.87

0.90

Average stiffness (%)

70.52 ± 10.89

69.83 ± 14.90

0.50

Estradiol (pmol/L)

27.51 ± 16.00

31.16 ± 18.36

0.27

SHBG (nmol/L)

55.03 ± 23.81

50.52 ± 19.73

0.33

Free estradiol index (units)

2.95 ± 3.01

2.50 ± 2.10

0.43

  1. Results in mean ± SD or number (percentage). P value generated using ANCOVA test or COX regression.