Table 4 Genotype association between BMP4.1 and BMP4.2 polymorphisms and NSCLP subdivided by gender
From: Risk variants in BMP4 promoters for nonsyndromic cleft lip/palate in a Chilean population
Males | Females | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Promoter | Polymorphism | Genotypes | Frequency | Odds Ratio (95% C.I.) | p-value | Frequency | Odds Ratio (95% C.I.) | p-value | ||
Cases | Controls | Cases | Controls | |||||||
rs2855527 | T/T | 0.9906 | 0.9946 | Ref. | 1.0000 | 0.9934 | Ref. | |||
BMP4.1 | T/G | 0.0094 | 0.0054 | 1.74 (0.10-28.16) | 0.692 | 0.0000 | 0.0065 | |||
rs77671695 | T/T | 0.92 | 0.89 | Ref. | 0.93 | 0.89 | Ref. | |||
T/G | 0.08 | 0.11 | 0.72 (0.32-1.63) | 0.431 | 0.07 | 0.11 | 0.64 (0.21-2.01) | 0.443 | ||
delAACCCGGG | Ins/Ins | 0.94 | 0.88 | Ref. | 0.88 | 0.88 | Ref. | |||
Ins/Del | 0.06 | 0.12 | 0.45 (0.17-1.15) | 0.090 | 0.12 | 0.12 | 1.01 (0.38-2.73) | 0.982 | ||
G/G | 0.17 | 0.14 | Ref. | 0.08 | 0.16 | Ref. | ||||
rs2855530 | C/G | 0.58 | 0.43 | 2.34 (1.33-4.09) | 0.011 | 0.50 | 0.45 | 2.23 (0.71-7.08) | 0.583 | |
BMP4.2 | C/C | 0.25 | 0.43 | 0.51 (0.23-1.09) | 0.003 | 0.42 | 0.39 | 2.21 (0.69-7.15) | 0.655 | |
rs113141288 | G/G | 0.91 | 0.90 | Ref. | 0.93 | 0.89 | Ref. | |||
G/T | 0.09 | 0.10 | 0.83 (0.36-1.93) | 0.677 | 0.07 | 0.11 | 0.64 (0.20-2.01) | 0.444 | ||
rs76953585 | C/C | 0.92 | 0.88 | Ref. | 0.91 | 0.90 | Ref. | |||
C/T | 0.08 | 0.12 | 0.69 (0.31-1.59) | 0.392 | 0.09 | 0.10 | 0.91 (0.31-2.62) | 0.857 | ||
rs113562279 | G/G | 0.93 | 0.88 | Ref. | 0.93 | 0.91 | Ref. | |||
G/T | 0.07 | 0.12 | 0.62 (0.26-1.44) | 0.261 | 0.07 | 0.09 | 0.77 (0.24-2.44) | 0.653 | ||