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Table 4 Population-based association analysis between CXCR1/CXCR2 and VL

From: Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India

Common Designation

Allele

Affected

Unaffected

OR

L95

U95

P-values

CXCR2_rs4674259

T

840/1036

816/1160

1.15

1.01

1.31

0.027

CXCR1_rs2234671

G

286/1592

321/1657

0.92

0.77

1.10

0.384

CXCR1_rs3138060

C

197/1685

252/1732

1.25

1.02

1.53

0.028

  1. Logistic regression analyses under an additive model for the replication sample of VL cases and controls. OR = odds ratio; L95 and U95 are lower and upper 95% confidence intervals. Allele counts are shown for minor/major allele for affected and unaffected individuals. Bold indicates associations significant at nominal P ≤ 0.05. The corrected P-value required to achieve significance taking account of 3 independent SNPs is P ≤ 0.017.