Common Designation | Allele | Allele frequency | # Fam | S | E(S) | Var(S) | Z |
P
|
|---|
CXCR2_rs4674259 | T | 0.53 | 105 | 196 | 194 | 57.313 | 0.216 | 0.829 |
CXCR2_rs4674259 | C | 0.47 | 105 | 184 | 186 | 57.313 | -0.216 | 0.829 |
CXCR1_rs2234671
| G | 0.85 | 69 | 181 | 165 | 31.519 | 2.935 |
0.003
|
CXCR1_rs2234671
| C | 0.15 | 69 | 61 | 77 | 31.519 | -2.935 |
0.003
|
CXCR1_rs3138060
| G | 0.12 | 49 | 49 | 59 | 22.187 | -2.222 |
0.026
|
CXCR1_rs3138060
| C | 0.88 | 49 | 133 | 122 | 22.187 | 2.222 |
0.026
|
- Single point FBAT analysis under an additive model of inheritance for associations between CXCR1/CXCR2 polymorphisms and VL in the primary family-based sample set. # Fam = number of families informative for the FBAT analysis; S and E(S) represent the observed and expected transmissions for that allele, Var(S) is the variance. A positive Z score indicates association with disease; a negative Z score indicates the non-associated or protective allele or genotype. Bold indicates significant associations at nominal P ≤ 0.05. The corrected P-value required to achieve significance taking account of 3 independent SNPs is P ≤ 0.017.
