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Table 3 Major Haplotype Distribution in Case and Control Subjects by Race in stage 1†‡

From: Genetic variation of Glucose Transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) Study

European Americans

Haplotype

Promoter SNP

Intron-1 SNP1

Intron-1 SNP2

Enh2SNP

XbaI SNP

Intron-2 SNP

Controls

Albuminuria Cases

P-value

N = 3326 Haplotypes

A

C

A

C

C

C

C

(43.4)

(39.5)

0.773

 

B

A

A

C

T

A

C

(17.2)

(18.9)

 
 

C

A

C

A

C

C

A

(14.1)

(14.5)

 
 

D

C

A

C

T

A

C

(6.2)

(6.8)

 
 

Others

*

*

*

*

*

*

(19.1)

(20.3)

 

African Americans

          

N = 2156 Haplotypes

A

C

A

C

C

C

C

(13.7)

(10.7)

0.877

 

B

A

A

C

T

A

C

(5.4)

(5.0)

 
 

C

A

C

A

C

C

A

(7.7)

(9.6)

 
 

E

C

C

C

C

C

C

(14.0)

(13.9)

 
 

F

C

C

C

C

A

C

(11.0)

(12.1)

 
 

G

A

C

C

C

A

C

(12.7)

(11.4)

 
 

H

A

C

A

C

C

C

(11.9)

(12.1)

 
 

I

A

A

C

C

A

C

(6.8)

(7.5)

 
 

Others

*

*

*

*

*

*

(16.8)

(17.5)

 
  1. ‡ Major haplotypes have a frequency ≥ 5%. Minor alleles are shaded in gray. Bonferroni corrected level of statistical significance for European Americans p < 0.0125 and for African Americans p < 0.00625.
  2. † Among European Americans, the ten diplotypes associated with the major haplotypes A, B, C, and D from table 3, only the BD diplotype was associated with albuminuria (OR 3.03, 95% CI 1.36 - 6.79, p = 0.007, compared to individuals without the BD diplotype). However, this did not reach a Bonferroni corrected level of statistical significance of p < 0.005. The diplotypes consisting of the B or D "risk" haplotypes were rare, with BB, BD, and DD diplotypes accounting for 2.7%, 2.2%, and 0.5% of the 1663 European Americans with available diplotypes analyzed.
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BMC Medical Genetics

ISSN: 1471-2350

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