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Table 2 Top meta-analysis results.

From: Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development

  

Individual Study P-value

Meta-analysis P-value

SNP

bp

Breast1

Prostate1

Pancreatic1

Lung1

Lung2

Ovarian3

Ovarian4

Glioma5

Colon6

Fisher

Stouffer

Binomial

rs1695718

118458790

0.14

0.40

0.82

0.19

-

0.95

0.03

5.45E-05

0.23

7.94E-04

8.92E-03

0.19

rs7846200

120576453

1.08E-03

0.18

7.52E-04

6.20E-03

-

0.87

0.61

0.40

0.39

1.51E-05

1.01E-04

0.04

rs7000665

120576919

1.73E-03

0.22

1.12E-04

8.44E-03

-

0.90

0.54

0.62

0.45

1.11E-05

2.39E-04

0.04

rs10505364

120578285

1.53E-03

0.27

2.97E-04

3.16E-03

0.75

0.82

0.46

0.37

0.39

2.94E-05

3.72E-04

0.05

rs9643136

120609324

5.45E-04

0.34

1.15E-04

5.30E-03

0.50

0.99

0.58

0.70

0.36

1.36E-05

1.78E-03

0.05

rs6993464

120614129

2.17E-03

0.17

6.39E-05

6.45E-04

-

0.81

0.22

0.21

0.24

1.25E-07

6.92E-07

0.04

rs11782176

120617858

2.16E-03

0.20

5.55E-05

5.61E-04

-

0.76

-

0.24

0.25

5.24E-07

6.86E-06

0.03

rs6991756

120626148

4.33E-03

0.24

5.01E-05

1.15E-03

1.00

0.69

0.24

0.24

0.23

3.17E-06

1.34E-04

0.05

rs3870371

122766313

4.23E-05

0.57

0.62

0.38

0.82

0.23

0.16

0.69

0.72

9.12E-03

0.12

0.61

rs920455

122769378

3.30E-05

0.65

0.64

0.41

0.68

0.16

0.18

0.85

0.76

9.26E-03

0.17

0.61

rs6470494

128157086

9.43E-04

0.36

0.16

0.96

0.57

2.88E-03

0.93

0.57

5.85E-04

3.73E-05

1.60E-03

0.05

rs17464492

128412048

0.21

0.04

0.08

0.92

0.09

6.14E-03

1.21E-02

0.72

1.18E-02

3.92E-04

4.80E-04

6.42E-05

rs10808555

128478693

6.35E-03

1.29E-02

0.81

0.05

0.05

3.87E-03

0.78

0.53

8.82E-03

4.64E-05

1.91E-04

6.42E-05

rs6983267

128482487

8.37E-03

1.05E-05

0.25

0.39

0.16

0.02

0.81

0.49

1.40E-03

6.34E-08

1.28E-06

8.33E-03

rs7837328

128492309

3.88E-03

8.68E-04

0.63

0.23

-

9.83E-03

0.84

0.62

1.41E-02

4.40E-05

3.02E-04

5.02E-03

rs7014346

128493974

6.19E-03

2.83E-03

0.69

0.18

0.23

0.02

0.98

0.49

1.02E-02

8.48E-05

6.32E-04

8.33E-03

rs12334695

128523110

0.14

4.34E-04

0.02

0.53

0.96

0.03

0.74

3.09E-02

0.47

8.46E-05

4.43E-04

8.33E-03

rs1447295

128554220

0.64

2.44E-05

0.52

0.46

0.24

0.17

0.27

0.12

0.73

1.26E-03

1.45E-02

0.61

rs4242382

128586755

0.83

2.82E-06

0.43

0.60

0.13

0.19

0.16

0.13

0.99

2.26E-04

0.06

0.61

rs4242384

128587736

0.87

2.66E-06

0.49

0.58

-

0.21

0.30

0.17

0.95

1.08E-03

0.11

0.57

rs7017300

128594450

0.73

1.80E-05

0.85

0.95

0.15

0.39

0.60

8.45E-02

0.58

2.03E-03

0.09

0.23

rs11988857

128601055

0.65

3.78E-06

0.97

0.87

-

0.16

0.37

5.68E-02

0.97

1.12E-03

0.29

0.19

rs7837688

128608542

0.88

1.02E-06

0.65

0.92

0.11

0.22

0.23

5.37E-02

0.74

7.80E-05

0.02

0.23

rs4404878

128867576

0.89

0.21

3.02E-05

0.06

0.50

0.05

0.17

0.10

0.97

3.20E-04

0.02

0.05

rs7841347

128887490

0.82

0.09

3.25E-05

0.06

0.38

0.54

0.27

0.25

0.86

7.96E-04

1.68E-02

0.05

rs16903097

129625538

0.59

0.92

0.39

0.05

-

1.98E-02

9.16E-05

0.14

0.33

1.08E-02

0.03

0.04

rs2163951

130672539

0.43

0.81

0.56

0.46

0.51

0.87

0.98

0.65

9.72E-05

0.03

0.35

0.61

rs6470863

132015998

0.55

0.32

0.87

5.38E-05

0.88

0.80

0.63

0.20

0.41

0.14

0.33

0.61

  1. SNP markers with p ≤ .0001 (bold) for either the individual GWAS or the meta-analysis with SNP present in at least five studies, sorted based on base-pair position (bp) on chromosome 8. A dash indicates no data.
  2. Results from 1CGEMS, 2Li et al [32], 3Song et al [35]; 4Permuth-Wey et al [36]; 5Wrensch et al [34]; 6CFR [33]
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BMC Medical Genetics

ISSN: 1471-2350

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