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Table 5 Meta-analysis of effects of rs9514089 on serum cholesterol and triglyceride levels in the Sorbs, Aachen cohort and Stuttgart cohort

From: Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts

  Sorbs   Aachen   Stuttgart    
Trait p (ADD) beta (ADD) p (ADD) beta (ADD) p (ADD) beta (ADD) p meta beta meta
   [95% CI]   [95% CI]   [95% CI]   [95% CI]
total cholesterol [mmol/l] 0.17 0.01 0.28 -0.024 0.06 -0.048 0.91 0.001
   [-0.005; 0.028]   [-0.067; 0.019]   [-0.097; 0.001]   [-0.014; 0.016]
triglycerides [mmol/l] 0.41 0.018 0.92 -0.004 0.37 -0.062 0.69 0.007
   [-0.025; 0.061]   [-0.078; 0.070]   [-0.197; 0.073]   [-0.029; 0.043]
  1. Meta-analysis of three independent cohorts (Sorbs N = 907, Aachen N = 358, Stuttgart N = 122). Analyses were performed under the additive mode of inheritance in a fixed effects model. Only subjects without any lipid-lowering medication were included in the analyses. Results were assessed in a linear regression model adjusted for age, sex and BMI and effect directions are standardized to the minor allele.